| Tag |
Content |
| dbPAF ID |
dbPAF-0044137 |
| Uniprot Accession |
Q9Y7Z8; MYO1_SCHPO;
|
| Genbank Protein ID |
NP_595402.1;
|
| Genbank Nucleotide ID |
NM_001021309.2;
|
| Protein Name |
Myosin-1 |
| Protein Synonyms/Alias |
Class I unconventional myosin;Type I myosin; |
| Gene Name |
myo1 |
| Gene Synonyms/Alias |
SPBC146.13c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating.Functional Description
Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MAILKRTNRA KAATAAAPNS TGKSNGIKKA VYTSTRKKTV GVDDLTLLSK ITDEEINKNL 60
ELRFRNGEIY TYIGHVLISV NPFRDLGIYT MDILKSYQGK NRLETSPHVY AIAENAYYQM 120
KSYHENQCII ISGESGAGKT EAAKRIMQYI THVSKSVGTE IERVSEIILA TNPLLESFGC 180
AKTLRNNNSS RHGKYLEMIF NSGGVPVGAK ITNYLLEKNR IVNQVRNERN FHIFYQFTKS 240
APQKYRDTYG IQGPENYVYT SACQCLSVDG ISDEKDFQGT MNAMKVIGIT EPEQDEIFRM 300
LSIILWLGNI QFQEGQDGGS VISDKSITEF LGYLIGVPVA AIERALTIRI MQTQHGARRG 360
SVYEVPLNPT QALAVRDALS MAIYNCLFDW IVERVNKALV TSDNSVSNSI GILDIYGFEI 420
FENNSFEQLC INYVNEKLQQ IFIELTLKTE QEEYVREQIA WTPIKYFNNK VVCDLIESKR 480
PPGLFAAMND AIATAHADSA AADSAFAQRL NFLSSNPHFE QRQNQFIVKH YAGDVTYSIT 540
GMTDKNKDQL ATDILNLIHS SNNEFMKSIF PVAEESNSRR RPPTAGDRIK TSANDLVETL 600
MKCQPSYIRT IKPNQTKSPN DYDQQMVLHQ IKYLGLQENI RIRRAGFAYR QAFDTFAQRF 660
AVLSGKTSYA GEYTWQGDDK SACEQILKDT NIPSSEYQMG TSKVFIKNPE TLFALEDMRD 720
KFWDTMATRI QRAWRSYVRR RSEAAACIQK LWNRNKVNME LERVRNEGTK LLQGKKQRRR 780
YSILGSRKFY GDYLSASKPN GTLWNTCGLS QNDHVIFSMR CEVLVHKLGR TSKPSPRQLV 840
LTKKNLYLVI TKIVDQKLTQ QVEKKFAVSS IDSVGLTNLQ DDWVAIRNKS SQNGDMFLRC 900
FFKTEFITTL KRINRNIQVI VGPTIQYCRK PGKVQTVKTA KDETTKDYDY YKSGTIHVGT 960
GLPPTSKSKP FPRLATGGST AAARGPRPVV QNKPAATKPV SMPAAKSKPA PMANPVSTAQ 1020
QTQNRPPAPA MQARPNTTQA AAPVTSTTTT IKQATTVSAS KPAPSTVTSA ASSPSNISKP 1080
SAPVANNVSK PSAVPPPPPP PPAEVEKKDL YLALYDFAGR SPNEMTIKKD EIIEIVQKEP 1140
SGWWLALKNG AEGWVPATYV TEYKGSTPQT TASSTNVAAQ ANNNASPAEV NNLAGSLADA 1200
LRMRASAVRG SDEEEDW
1218Fasta Sequence
>Q9Y7Z8|myo1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MAILKRTNRAKAATAAAPNSTGKSNGIKKAVYTSTRKKTVGVDDLTLLSKITDEEINKNLELRFRNGEIYTYIGHVLISVNPFRDLGIYTMDILKSYQGKNRLETSPHVYAIAENAYYQMKSYHENQCIIISGESGAGKTEAAKRIMQYITHVSKSVGTEIERVSEIILATNPLLESFGCAKTLRNNNSSRHGKYLEMIFNSGGVPVGAKITNYLLEKNRIVNQVRNERNFHIFYQFTKSAPQKYRDTYGIQGPENYVYTSACQCLSVDGISDEKDFQGTMNAMKVIGITEPEQDEIFRMLSIILWLGNIQFQEGQDGGSVISDKSITEFLGYLIGVPVAAIERALTIRIMQTQHGARRGSVYEVPLNPTQALAVRDALSMAIYNCLFDWIVERVNKALVTSDNSVSNSIGILDIYGFEIFENNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIAWTPIKYFNNKVVCDLIESKRPPGLFAAMNDAIATAHADSAAADSAFAQRLNFLSSNPHFEQRQNQFIVKHYAGDVTYSITGMTDKNKDQLATDILNLIHSSNNEFMKSIFPVAEESNSRRRPPTAGDRIKTSANDLVETLMKCQPSYIRTIKPNQTKSPNDYDQQMVLHQIKYLGLQENIRIRRAGFAYRQAFDTFAQRFAVLSGKTSYAGEYTWQGDDKSACEQILKDTNIPSSEYQMGTSKVFIKNPETLFALEDMRDKFWDTMATRIQRAWRSYVRRRSEAAACIQKLWNRNKVNMELERVRNEGTKLLQGKKQRRRYSILGSRKFYGDYLSASKPNGTLWNTCGLSQNDHVIFSMRCEVLVHKLGRTSKPSPRQLVLTKKNLYLVITKIVDQKLTQQVEKKFAVSSIDSVGLTNLQDDWVAIRNKSSQNGDMFLRCFFKTEFITTLKRINRNIQVIVGPTIQYCRKPGKVQTVKTAKDETTKDYDYYKSGTIHVGTGLPPTSKSKPFPRLATGGSTAAARGPRPVVQNKPAATKPVSMPAAKSKPAPMANPVSTAQQTQNRPPAPAMQARPNTTQAAAPVTSTTTTIKQATTVSASKPAPSTVTSAASSPSNISKPSAPVANNVSKPSAVPPPPPPPPAEVEKKDLYLALYDFAGRSPNEMTIKKDEIIEIVQKEPSGWWLALKNGAEGWVPATYVTEYKGSTPQTTASSTNVAAQANNNASPAEVNNLAGSLADALRMRASAVRGSDEEEDW
|
| Keyword |
KW-0009--Actin-binding
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0505--Motor protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
|
| Interpro |
IPR001609--Myosin_head_motor_dom
IPR010926--Myosin_TH1
IPR027417--P-loop_NTPase
IPR001452--SH3_domain
|
| PROSITE |
PS51456--MYOSIN_MOTOR
PS50002--SH3
PS51757--TH1
|
| Pfam |
PF00063--Myosin_head
PF06017--Myosin_TH1
PF00018--SH3_1
|
| Gene Ontology |
GO:0030479--C:actin cortical patch
GO:0005826--C:actomyosin contractile ring
GO:0051286--C:cell tip
GO:0005737--C:cytoplasm
GO:0043332--C:mating projection tip
GO:0031097--C:medial cortex
GO:0045160--C:myosin I complex
GO:0044853--C:plasma membrane raft
GO:0005628--C:prospore membrane
GO:0030427--C:site of polarized growth
GO:0005524--F:ATP binding
GO:0000146--F:microfilament motor activity
GO:0005543--F:phospholipid binding
GO:0000147--P:actin cortical patch assembly
GO:0051666--P:actin cortical patch localization
GO:0030036--P:actin cytoskeleton organization
GO:0007015--P:actin filament organization
GO:0045010--P:actin nucleation
GO:0030476--P:ascospore wall assembly
GO:0006897--P:endocytosis
GO:0071963--P:establishment or maintenance of cell polarity regulating cell shape
GO:0044855--P:plasma membrane raft distribution
GO:0051127--P:positive regulation of actin nucleation
GO:0030100--P:regulation of endocytosis
|
