| Tag |
Content |
| dbPAF ID |
dbPAF-0044131 |
| Uniprot Accession |
Q9Y7U6; RGF1_SCHPO;
|
| Genbank Protein ID |
NP_588116.1;
|
| Genbank Nucleotide ID |
NM_001023106.2;
|
| Protein Name |
Rho1 guanine nucleotide exchange factor 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
rgf1 |
| Gene Synonyms/Alias |
SPCC645.07; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth.Functional Description
Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MDYRHPNALG VNESSRAYEE IFGAPRKREP ARTVSTPAFM EPAPVSKKPL PPPTRRLPRK 60
PLPFRSTSLQ PPSSQPPAPP THQREASPVK NIEHSESFPS VFGTSNNHQI VPLTLKDGND 120
FGALYASLNT TPHFPQVSNH APNNSNSPSL TWHTSSGDDS NQNPFFVRRQ SQSSTSPVSD 180
SVDENLLSAV SSVTESVETN LHLDQNYPYG SPVRSSKNPF LSSNSRLPTD DSSHTVGSHS 240
FTSGTHPPIV SSNSAFTLPN AVTPAAQAPL IRSVSEYPAN VSPPAQSLQL PKSTSNPADL 300
HLSIASASSH KNIFSGLDVF SNVFHGPSTT LRDREHDMRN RSFDHSTLAH YEAVKQQRLG 360
VEPTARSFTL SSYKSRASGN SLINDRSSTT TPTFVNSEAS SPVHKNKRRR RIYAALLSRV 420
ASELLDRLQL GDITKDGLIY SNAFTGDHAV TVLMGIIHTS DRNLALLVGR SLDAQKFIHD 480
VTYDHRLRDS HREIYQLQGT GYRPFLRAND NASINNKNHH KELEDNESGT RISPSTLGDT 540
SFPNGIFTLL THCYSPTCAK DHPCYSISCP RRLEQQHRLF AKMRANTEQS SSLAFDDKEQ 600
KLWIHSVPQE IAYSVSDRER KRQEVICEVI YTERDFVKDL EYLRDYWIKP LWASSCIPER 660
KKEKFIRTVF LNALEVQAVN SKLAEALTKR QNYKPIVDNI ADIFLEHVPK FEPFIRYGAG 720
QLYGKYEFEK EKSSNPAFAK FVSDVERLKE SRKLELNGYL TKPTTRLARY PLLLEAVLKY 780
TDEGNPDKQD IPKVINIVRG FLSRLNVESG KAENKFNLFH LNQQLVFKPG EHYDLHLLDA 840
NRQLIFKGPL KKRSAGSTSS ESASDVTLFL FDHALLIVKP KTINKRELLK VFQRPIPLLL 900
LQLFLVDDNG LRIPYSSKQQ LAAVSKAANG KPPSRFYPFS LQLLGRRGYE ITLYATTEVS 960
RDKWLEHIDN QQTLLQHRNQ WFESVTICSN FFVGDNKVNA IGVYDSGRRL LYGTDTGVYV 1020
SLRKANSPLQ FKPVRALNIP NISQLEVIEE YSLLLLLSDK VLYSYPLEMI DADTTQAPKK 1080
ARKVSGHTTF FRVGICLGKV LVCAVKSSVL SATIKVFEPV TNYSKTRNMP SLKKFLTVNQ 1140
DPLRIVKELY IPTESTSVHF LKNKLCVGCT RGFEVVSLDN LETQSLLDPA DTSLEFVEKK 1200
ENVKPIAIYR MNGGEFLLCY SQFAFYVNRD GWRSRPTWFV VWEGSPQNFA LSYPYILAFE 1260
PTFIEIRHVE TSELIHVISG RNIRLLADGR GKLGDGGEIF YACDQRGENC ETSVVCSLRL 1320
TSAAAHAKEQ HVDK
1335Fasta Sequence
>Q9Y7U6|rgf1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MDYRHPNALGVNESSRAYEEIFGAPRKREPARTVSTPAFMEPAPVSKKPLPPPTRRLPRKPLPFRSTSLQPPSSQPPAPPTHQREASPVKNIEHSESFPSVFGTSNNHQIVPLTLKDGNDFGALYASLNTTPHFPQVSNHAPNNSNSPSLTWHTSSGDDSNQNPFFVRRQSQSSTSPVSDSVDENLLSAVSSVTESVETNLHLDQNYPYGSPVRSSKNPFLSSNSRLPTDDSSHTVGSHSFTSGTHPPIVSSNSAFTLPNAVTPAAQAPLIRSVSEYPANVSPPAQSLQLPKSTSNPADLHLSIASASSHKNIFSGLDVFSNVFHGPSTTLRDREHDMRNRSFDHSTLAHYEAVKQQRLGVEPTARSFTLSSYKSRASGNSLINDRSSTTTPTFVNSEASSPVHKNKRRRRIYAALLSRVASELLDRLQLGDITKDGLIYSNAFTGDHAVTVLMGIIHTSDRNLALLVGRSLDAQKFIHDVTYDHRLRDSHREIYQLQGTGYRPFLRANDNASINNKNHHKELEDNESGTRISPSTLGDTSFPNGIFTLLTHCYSPTCAKDHPCYSISCPRRLEQQHRLFAKMRANTEQSSSLAFDDKEQKLWIHSVPQEIAYSVSDRERKRQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKEKFIRTVFLNALEVQAVNSKLAEALTKRQNYKPIVDNIADIFLEHVPKFEPFIRYGAGQLYGKYEFEKEKSSNPAFAKFVSDVERLKESRKLELNGYLTKPTTRLARYPLLLEAVLKYTDEGNPDKQDIPKVINIVRGFLSRLNVESGKAENKFNLFHLNQQLVFKPGEHYDLHLLDANRQLIFKGPLKKRSAGSTSSESASDVTLFLFDHALLIVKPKTINKRELLKVFQRPIPLLLLQLFLVDDNGLRIPYSSKQQLAAVSKAANGKPPSRFYPFSLQLLGRRGYEITLYATTEVSRDKWLEHIDNQQTLLQHRNQWFESVTICSNFFVGDNKVNAIGVYDSGRRLLYGTDTGVYVSLRKANSPLQFKPVRALNIPNISQLEVIEEYSLLLLLSDKVLYSYPLEMIDADTTQAPKKARKVSGHTTFFRVGICLGKVLVCAVKSSVLSATIKVFEPVTNYSKTRNMPSLKKFLTVNQDPLRIVKELYIPTESTSVHFLKNKLCVGCTRGFEVVSLDNLETQSLLDPADTSLEFVEKKENVKPIAIYRMNGGEFLLCYSQFAFYVNRDGWRSRPTWFVVWEGSPQNFALSYPYILAFEPTFIEIRHVETSELIHVISGRNIRLLADGRGKLGDGGEIFYACDQRGENCETSVVCSLRLTSAAAHAKEQHVDK
|
| Keyword |
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0344--Guanine-nucleotide releasing factor
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0717--Septation
|
| Interpro |
IPR001180--CNH_dom
IPR000591--DEP_dom
IPR000219--DH-domain
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR011991--WHTH_DNA-bd_dom
|
| PROSITE |
PS50219--CNH
PS50010--DH_2
PS50003--PH_DOMAIN
|
| Pfam |
PF00780--CNH
PF00610--DEP
PF00621--RhoGEF
|
| Gene Ontology |
GO:0000935--C:barrier septum
GO:0051285--C:cell cortex of cell tip
GO:0051286--C:cell tip
GO:0005634--C:nucleus
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0051666--P:actin cortical patch localization
GO:0000917--P:barrier septum assembly
GO:0009272--P:fungal-type cell wall biogenesis
GO:0035556--P:intracellular signal transduction
GO:0051518--P:positive regulation of bipolar cell growth
GO:0043547--P:positive regulation of GTPase activity
GO:0035025--P:positive regulation of Rho protein signal transduction
GO:0008360--P:regulation of cell shape
GO:0090334--P:regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
GO:0043087--P:regulation of GTPase activity
|
