| Tag |
Content |
| dbPAF ID |
dbPAF-0044130 |
| Uniprot Accession |
Q9Y7U5; RGF3_SCHPO;
|
| Genbank Protein ID |
NP_588115.1;
|
| Genbank Nucleotide ID |
NM_001023105.2;
|
| Protein Name |
Rho1 guanine nucleotide exchange factor 3 |
| Protein Synonyms/Alias |
Lethal at division protein 1; |
| Gene Name |
rgf3 |
| Gene Synonyms/Alias |
lad1;SPCC645.06c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3-glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly.Functional Description
Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3-glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MKLSNELFHR SSKDHGGKSR ICLDSSEDTY PPHSSSPPSF QKRLSFSDFS TTRLFSPPFL 60
SKRSNNSPHR FSYSPPQHPA SINSRRVASY TVQSSPSRTT YRQLPNEPQN SAAYTTYSSF 120
PNALFDDFSP NNPLDTDPFL TSPGNKQNTV DSFRPLPETP VSPGGSLVHP LPRPPLPSSV 180
SSHSSPYSTT SSTSLYSLYN DISLSCSPEP YLPLSPTRSP ARTPSPIRLY SSDALRPQSP 240
LSPSVEYLTP PNPYSLKSDI SSTRQLPKIP VQDYASGKIS SPLITRTHRR AQSETLFSSC 300
REPWLVGKLY KWCKEEVFTA LGGLVHEGVS RREVAQVMAT LFTIHIASME FLIAEIIAKN 360
ILGDWINYGL VEVINLEKLQ IAFTSNEPPS GSGVLPFLTN GGCYSYICRS RSCPSKYQCY 420
SCRCARNSSL EFTSLPGQSS DTWSIFWNIS SLNSLPSSLS KREIARQNNI HELICKESDY 480
VADLNTLAEL FRDGIVQQQD AIVPSNRVAD FIQSVFGNVE SIRQLHSRLF LPQLIMRERL 540
QGPVVSIIGD ILLEWIHAAK SSYINYAKQF PLADETYKLE CQRNTYFARW LAACRSDPRC 600
RRLDFQHFLQ RPTQRLQRYT LELDTILKHT EQSSWDFQLI TQAVKELRAT CEECDAVIAT 660
VLEANRIRDL SYQLLFKNHE SVNLELRDPE REFFFEGIVQ RRSDSRLDWL DIHLFLLDNY 720
LIMAKARKDK RTNASRYVVS KRPIPLDLLV LSPKMDDFQL KSNTNKFLGS LAGNLPQESL 780
TTKSKRKSKV NLELMFDATA EKNNENSMNS AVFEKSQLYP FTIRHLGAYT ASYTLYVESL 840
QLRKLWVEKI NVAKKRHSQK INIKNPFALK VVSDVAFQYP PSDLVNGNEP LNSFNEITLV 900
EGSSIDRALN EVAWKHPIVS EELLPEPIAY GDISCIAQFN DYEGHVSVLI ATSTGIFLGA 960
FGDSSDIRDW KKISSQRRVT QLGVVEEFDI LLELRDKTLY AHKLSRIIEM GLIESKIAVV 1020
IGTPHAVSFF KIGKLSEGAS VKRERTLVFY KEGLGNTTTI ICCEPVIGLG HNYQKTYAFK 1080
RKDVTSFRTL DDFHVTANCH SIDCFKYSIA LCHNKGIDVL RLDPKLAVGF PSPSVLNDTL 1140
FRNRINNSKP LGVFRIHDPS LFACCYQFGA VFVNGEGSMV NKECWFDWIG KPNSVTSCHG 1200
YLIAFNDEFV EIWNTRTRKL NQIIQGNDIK YYPSNSDWLA NGKYIMFGMV HPQYHDRHLI 1260
LALNKAKTNS FIIED
1276Fasta Sequence
>Q9Y7U5|rgf3|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MKLSNELFHRSSKDHGGKSRICLDSSEDTYPPHSSSPPSFQKRLSFSDFSTTRLFSPPFLSKRSNNSPHRFSYSPPQHPASINSRRVASYTVQSSPSRTTYRQLPNEPQNSAAYTTYSSFPNALFDDFSPNNPLDTDPFLTSPGNKQNTVDSFRPLPETPVSPGGSLVHPLPRPPLPSSVSSHSSPYSTTSSTSLYSLYNDISLSCSPEPYLPLSPTRSPARTPSPIRLYSSDALRPQSPLSPSVEYLTPPNPYSLKSDISSTRQLPKIPVQDYASGKISSPLITRTHRRAQSETLFSSCREPWLVGKLYKWCKEEVFTALGGLVHEGVSRREVAQVMATLFTIHIASMEFLIAEIIAKNILGDWINYGLVEVINLEKLQIAFTSNEPPSGSGVLPFLTNGGCYSYICRSRSCPSKYQCYSCRCARNSSLEFTSLPGQSSDTWSIFWNISSLNSLPSSLSKREIARQNNIHELICKESDYVADLNTLAELFRDGIVQQQDAIVPSNRVADFIQSVFGNVESIRQLHSRLFLPQLIMRERLQGPVVSIIGDILLEWIHAAKSSYINYAKQFPLADETYKLECQRNTYFARWLAACRSDPRCRRLDFQHFLQRPTQRLQRYTLELDTILKHTEQSSWDFQLITQAVKELRATCEECDAVIATVLEANRIRDLSYQLLFKNHESVNLELRDPEREFFFEGIVQRRSDSRLDWLDIHLFLLDNYLIMAKARKDKRTNASRYVVSKRPIPLDLLVLSPKMDDFQLKSNTNKFLGSLAGNLPQESLTTKSKRKSKVNLELMFDATAEKNNENSMNSAVFEKSQLYPFTIRHLGAYTASYTLYVESLQLRKLWVEKINVAKKRHSQKINIKNPFALKVVSDVAFQYPPSDLVNGNEPLNSFNEITLVEGSSIDRALNEVAWKHPIVSEELLPEPIAYGDISCIAQFNDYEGHVSVLIATSTGIFLGAFGDSSDIRDWKKISSQRRVTQLGVVEEFDILLELRDKTLYAHKLSRIIEMGLIESKIAVVIGTPHAVSFFKIGKLSEGASVKRERTLVFYKEGLGNTTTIICCEPVIGLGHNYQKTYAFKRKDVTSFRTLDDFHVTANCHSIDCFKYSIALCHNKGIDVLRLDPKLAVGFPSPSVLNDTLFRNRINNSKPLGVFRIHDPSLFACCYQFGAVFVNGEGSMVNKECWFDWIGKPNSVTSCHGYLIAFNDEFVEIWNTRTRKLNQIIQGNDIKYYPSNSDWLANGKYIMFGMVHPQYHDRHLILALNKAKTNSFIIED
|
| Keyword |
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0717--Septation
|
| Interpro |
IPR001180--CNH_dom
IPR000219--DH-domain
IPR011993--PH/PTB_dom
IPR001849--PH_domain
|
| PROSITE |
PS50219--CNH
PS50010--DH_2
PS50003--PH_DOMAIN
|
| Pfam |
PF00780--CNH
PF00621--RhoGEF
|
| Gene Ontology |
GO:0005826--C:actomyosin contractile ring
GO:0032153--C:cell division site
GO:0030428--C:cell septum
GO:0005829--C:cytosol
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0051666--P:actin cortical patch localization
GO:0000917--P:barrier septum assembly
GO:0043547--P:positive regulation of GTPase activity
GO:0030994--P:primary cell septum disassembly
GO:0060624--P:regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process
GO:0010590--P:regulation of cell separation after cytokinesis
GO:0090334--P:regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
|
