dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0044125
Uniprot Accession Q9Y7R4; SET1_SCHPO;
Genbank Protein ID NP_587812.1;
Genbank Nucleotide ID NM_001022805.2;
Protein Name Histone-lysine N-methyltransferase, H3 lysine-4 specific
Protein Synonyms/Alias COMPASS component set1;Lysine N-methyltransferase 2;SET domain-containing protein 1;Set1 complex component set1;Set1C component set1;Spset1;
Gene Name set1
Gene Synonyms/Alias kmt2;SPCC306.04c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
534TPVFSDTSDENDKFHcurated22817900
593AIKDELISPKKEIDEdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MDFNTSTRSK SQPVQRNNYK VLYDPELGIK ENLGRKIIYR FNGVSKPPLV VRDPRLKNPI 60
YARGIPKSGR PFLKSLQTIN YDYNENSLGP EPPTQVFVSN ISPLVTSEQL RYHFKSFGEV 120
FDLDLKLNPY TGTSLGLCCI SFDKRSSISV AAHSAKIAVQ QANGLRFSGK PLSVVLDRDG 180
SLCEEAFKKA LNAVEKQFQE ETLQKQRFER EDESSRQKLS AAMNEDIPPW RQPSKNSQTL 240
SNGDLQHSKV QNVDQKSGFL TSSETDVPKN INDYIYLLID DRFVPPDRVY YTDIKHHFRK 300
FLYEKIYMNK DGFYITFNNY REASNCYRAL DRTYVQNCRI KLKFHDIPSR TKEDGKKSAV 360
RRVVLPPEEA YAEATSVVLR DLEAALLRDV KSKIIGPAIF KYLHSMPKPS VKEELQENLL 420
VSSTSVPDVP LKIESTVGKL PSLPKFKKRV DSSKMNLSAG SKTKSKLQRR RRRRHEARPL 480
HYQLNQMYNS SASEAESDQE LLLSSGDERV ERGKIGSIKS VKSDEATPVF SDTSDENDKF 540
HRFRTKSKIS KKKYEKMEVD YTSSSETESD ASILSPSAAI PKSGSAIKDE LISPKKEIDE 600
VLALAPKWRI NEFDETGSVY YGALPYNYPE DDVLLDLDGL QYLVKNDEDY SYLQEALKDE 660
PLMDINDPNF WAYERKSCKF KNGDVKYGDT AILPEPKGYF RSNTSGSAKS EGYYIIPTTE 720
KSLYLPLRNR STIDTISHST SRITSRMNRV NNRRLAAGVE KSQLPAEADL LRFNALKARK 780
KQLHFGPSRI HTLGLFAMEN IDKNDMVIEY IGEIIRQRVA DNREKNYVRE GIGDSYLFRI 840
DEDVIVDATK KGNIARFINH SCAPNCIARI IRVEGKRKIV IYADRDIMHG EELTYDYKFP 900
EEADKIPCLC GAPTCRGYLN 921
Keyword

KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
Interpro

IPR024657--COMPASS_Set1_N-SET
IPR017111--Hist_H3-K4_MeTrfase_1_fun
IPR012677--Nucleotide-bd_a/b_plait
IPR003616--Post-SET_dom
IPR000504--RRM_dom
IPR024636--SET_assoc
IPR001214--SET_dom
PROSITE

PS50868--POST_SET
PS50102--RRM
PS51572--SAM_MT43_1
PS50280--SET
Pfam

PF11764--N-SET
PF00076--RRM_1
PF00856--SET
PF11767--SET_assoc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0048188--C:Set1C/COMPASS complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0070869--P:heterochromatin assembly involved in chromatin silencing
GO:0051568--P:histone H3-K4 methylation