dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0044108
Uniprot Accession Q9Y794; ORC4_SCHPO;
Genbank Protein ID NP_595825.1;
Genbank Nucleotide ID NM_001021729.2;
Protein Name Origin recognition complex subunit 4
Protein Synonyms/Alias
Gene Name orc4
Gene Synonyms/Alias orp4;SPBP23A10.13;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner. This binding is mediated by the N-terminal A.T hook repeats of orc4.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
405SLKHFAITSPNNQQFdbPTM 3.0;UniProt18257517; 16381945; 23193290
406LKHFAITSPNNQQFLdbPTM 3.0;UniProt18257517; 16381945; 23193290
503NFEVAIISPKKSQHKdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MSSSPFTNLG NLDTEAIYEN KENEYQTNIT NETSNVQNLS SGNDDQQYPN STNDDANNGL 60
TASQAKLQDI AAVTLFQDNN ISTTTLAPPS PSPLRLNEAP RRRGRPRKYP PKPIDEGSEP 120
IIKRKRGRPP KIKSSSPSTK LDDPLKPKRG RGRPRLHPLP VVQPSVDEGT TQNNLQMGLD 180
EPNIIEGFAE GHANLSELKP KRGRGRPRKI KPEEGSSSQN GLSPLVVLPA KRGRGRPPLH 240
RSEQKIANTP ISNNVTVEST GTNLHTHSQL NPENEQSSSE FYSLNPQSEI RKEVVVTDQP 300
LFSTADVPVK RKRGRPPLNK PKILFGTSTE NKIDENRPKR GRGRPRLERP SGLPLDSKSQ 360
SLFKRKRGRP PKIASGIVPL SAFTRKHEDM LHDSDALSLK HFAITSPNNQ QFLNNQQRES 420
APLLPRKRGR PPKKRQENAE IRNITPGLTD SSVHSSSATP QSESSSPNSV SPLLPSSDRL 480
PLLRQSQFTP PPKKPNFEVA IISPKKSQHK LYPNPVVESV FNDVPYSEID SQLHTIKSTI 540
AARLCGKSHI PLVGHMDEQT KLYQWVRQTI VLGEGNSVII VGPRGSGKSV LVDDILSRAA 600
QEINEKSYVV RLNGTYQTDD KLALREISRQ LSIELESIES DEALKSEMNF SDTLTKLLAT 660
LSHPVDLGIA EDVMTTSAAV IFVLEEFDLF VQHSRQMLLY NLFDIAQSRK APILIIGLTT 720
RYDCSESLEK RVKSRFSHMV IPMRPPSSLS EFEQILKSVL YVSDEGGKDQ IITCWNQRVD 780
ELLSDTRSHL HKLVQHHYFA SRNLKLLYVD LLFPILSMAP DRPLLADEDF ANISLKVSDH 840
KVELVKNLSL LELALLICAV RFEARDIPAC NFNSAYQEYR QLHQSSVINA AASGALAHSS 900
RLWGRDVALE AWETLGSIGL IIPVHPSTNV SGALSRQCQL WQPEVDINVV SVGLREHRRL 960
PSHYYRWLKE VI 973
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR003593--AAA+_ATPase
IPR020478--AT_hook-like
IPR017956--AT_hook_DNA-bd_motif
IPR027417--P-loop_NTPase
PROSITE
Pfam

PF02178--AT_hook
Gene Ontology

GO:0031261--C:DNA replication preinitiation complex
GO:0000790--C:nuclear chromatin
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005656--C:nuclear pre-replicative complex
GO:0043596--C:nuclear replication fork
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003688--F:DNA replication origin binding
GO:0006270--P:DNA replication initiation
GO:0006265--P:DNA topological change
GO:1902975--P:mitotic DNA replication initiation
GO:1902597--P:positive regulation of DNA replication origin binding