dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0040934 |
| Uniprot Accession | Q9UUM2; SWI1_SCHPO; Q9Y7X0; |
| Genbank Protein ID | NP_595358.1; |
| Genbank Nucleotide ID | NM_001021265.2; |
| Protein Name | Mating-type switching protein swi1 |
| Protein Synonyms/Alias | Replication fork protection complex subunit swi1; |
| Gene Name | swi1 |
| Gene Synonyms/Alias | SPBC216.06c; |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID | 284812 |
| Functional Description (View all) |
Forms a fork protection complex (FPC) with swi3. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. It is required for programmed fork-pausing which is necessary for mating-type switching. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors. It is involved in termination at the mat1-proximal polar-terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MELDEVIQGI VSAIGGFDYS DDEKVYVLGD EALACLKDLK RYLQVVDEKY KVWQIRSLLS 60 SLQLVTNDIC PILSDWDKDI TNYRNWRIAL ACVELLVPLT WPLETEHETF RENVDVLYNL 120 RQAQSNYKNS ILSYKKGSVL SAILAVLLKP LSTPAESRTL RDKGIIRIVL LLFRNILQID 180 ELKTKNETII SFAKAHILDL IVTLVSNLDE FEHFDVYILE IVYNLIRGCK PSALFSDASL 240 TNSQTELNSL LLKESTQNRY LKRNAHTRHN RFGTMLSVQT EDRRFTIASQ NIKTDGLDEL 300 DSHKRFRKRG TRRKHFDDIN KSFFINTEAG TALRNFAVEF LEAGFNPLFQ SLLKDLERED 360 PRVLPIHKMQ LLYVQSFFLE FMRFSSKPKK TEEIYSNDYS FGLAASVFDQ RALIMHNRLM 420 VESFEMKQWS TFQASMLSMT QLLFTLRSMT LCSSEIYQRI ADNLLSNIFY QEEILLLVYS 480 ALKHFKTQSF GYLDAITELT IVLLKELEKF SSAKQYLYVK KRRRNQKSVD SNVLESDEDE 540 ESSLINANAA VEDRLFDFGR YESRYCDNGC IDSFVLFLQC YQDLDSKQIH RAISFFYRIF 600 VKQKCHVYLY RLDFLRVLDK MFNDHVYFST TNSARQDFEQ FFVYYMRKLS DALKDVPALF 660 IELPFPKLTD TFYYLEYGKS PLFSIHGSRK GPLYETVPGL SHLEKVAAVV ACLINENKSD 720 LLDELKVQLN CLISERKLIT LADENKYINE GGNDGERMGK NLKGDTDSFN TALLKDGKFR 780 LLLELCGFEE SDNNIDVQAL WKLPNSVIID ELVEHAMLLR RFTDDPPTFE GTKPEDLLVR 840 KQRGNVRLPS SSEGETSDEE IEFEADDPIT FANRREALNK ITDRKRKKMK TNETIIDHTT 900 RKKKENHLRS AKYIVDSDDD SETDIAFFQS EAALREKNAQ KASALFKRID DLEMEGKLQE 960 IEQLSENSSS D 972 |
| Keyword | KW-0131--Cell cycle |
| Interpro | |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0044732--C:mitotic spindle pole body |