| Tag |
Content |
| dbPAF ID |
dbPAF-0040915 |
| Uniprot Accession |
Q9UUG0; FAS1_SCHPO; P78799;
|
| Genbank Protein ID |
NP_594370.1;
|
| Genbank Nucleotide ID |
NM_001019791.2;
|
| Protein Name |
Fatty acid synthase subunit beta |
| Protein Synonyms/Alias |
|
| Gene Name |
fas1 |
| Gene Synonyms/Alias |
SPAC926.09c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.Functional Description
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MVEAEQVHQS LRSLVLSYAH FSPSILIPAS QYLLAAQLRD EFLSLHPAPS AESVEKEGAE 60
LEFEHELHLL AGFLGLIAAK EEETPGQYTQ LLRIITLEFE RTFLAGNEVH AVVHSLGLNI 120
PAQKDVVRFY YHSCALIGQT TKFHGSALLD ESSVKLAAIF GGQGYEDYFD ELIELYEVYA 180
PFAAELIQVL SKHLFTLSQN EQASKVYSKG LNVLDWLAGE RPERDYLVSA PVSLPLVGLT 240
QLVHFSVTAQ ILGLNPGELA SRFSAASGHS QGIVVAAAVS ASTDSASFME NAKVALTTLF 300
WIGVRSQQTF PTTTLPPSVV ADSLASSEGN PTPMLAVRDL PIETLNKHIE TTNTHLPEDR 360
KVSLSLVNGP RSFVVSGPAR SLYGLNLSLR KEKADGQNQS RIPHSKRKLR FINRFLSISV 420
PFHSPYLAPV RSLLEKDLQG LQFSALKVPV YSTDDAGDLR FEQPSKLLLA LAVMITEKVV 480
HWEEACGFPD VTHIIDFGPG GISGVGSLTR ANKDGQGVRV IVADSFESLD MGAKFEIFDR 540
DAKSIEFAPN WVKLYSPKLV KNKLGRVYVD TRLSRMLGLP PLWVAGMTPT SVPWQFCSAI 600
AKAGFTYELA GGGYFDPKMM REAIHKLSLN IPPGAGICVN VIYINPRTYA WQIPLIRDMV 660
AEGYPIRGVT IAAGIPSLEV ANELISTLGV QYLCLKPGSV EAVNAVISIA KANPTFPIVL 720
QWTGGRAGGH HSFEDFHSPI LLTYSAIRRC DNIVLIAGSG FGGADDTEPY LTGEWSAAFK 780
LPPMPFDGIL FGSRLMVAKE AHTSLAAKEA IVAAKGVDDS EWEKTYDGPT GGIVTVLSEL 840
GEPIHKLATR GIMFWKELDD TIFSLPRPKR LPALLAKKQY IIKRLNDDFQ KVYFPAHIVE 900
QVSPEKFKFE AVDSVEDMTY AELLYRAIDL MYVTKEKRWI DVTLRTFTGK LMRRIEERFT 960
QDVGKTTLIE NFEDLNDPYP VAARFLDAYP EASTQDLNTQ DAQFFYSLCS NPFQKPVPFI 1020
PAIDDTFEFY FKKDSLWQSE DLAAVVGEDV GRVAILQGPM AAKHSTKVNE PAKELLDGIN 1080
ETHIQHFIKK FYAGDEKKIP IVEYFGGVPP VNVSHKSLES VSVTEEAGSK VYKLPEIGSN 1140
SALPSKKLWF ELLAGPEYTW FRAIFTTQRV AKGWKLEHNP VRRIFAPRYG QRAVVKGKDN 1200
DTVVELYETQ SGNYVLAARL SYDGETIVVS MFENRNALKK EVHLDFLFKY EPSAGYSPVS 1260
EILDGRNDRI KHFYWALWFG EEPYPENASI TDTFTGPEVT VTGNMIEDFC RTVGNHNEAY 1320
TKRAIRKRMA PMDFAIVVGW QAITKAIFPK AIDGDLLRLV HLSNSFRMVG SHSLMEGDKV 1380
TTSASIIAIL NNDSGKTVTV KGTVYRDGKE VIEVISRFLY RGTFTDFENT FEHTQETPMQ 1440
LTLATPKDVA VLQSKSWFQL LDPSQDLSGS ILTFRLNSYV RFKDQKVKSS VETKGIVLSE 1500
LPSKAIIQVA SVDFQSVDCH GNPVIEFLKR NGKPIEQPVE FENGGYSVIQ VMDEGYSPVF 1560
VTPPTNSPYA EVSGDYNPIH VSPTFAAFVE LPGTHGITHG MYTSAAARRF VETYAAQNVP 1620
ERVKHYEVTF VNMVLPNTEL ITKLSHTGMI NGRKIIKVEV LNQETSEPVL VGTAEVEQPV 1680
SAYVFTGQGS QEQGMGMDLY ASSPVARKIW DSADKHFLTN YGFSIIDIVK HNPHSITIHF 1740
GGSKGKKIRD NYMAMAYEKL MEDGTSKVVP VFETITKDST SFSFTHPSGL LSATQFTQPA 1800
LTLMEKSAFE DMRSKGLVQN DCAFAGHSLG EYSALSAMGD VLSIEALVDL VFLRGLTMQN 1860
AVHRDELGRS DYGMVAANPS RVSASFTDAA LRFIVDHIGQ QTNLLLEIVN YNVENQQYVV 1920
SGNLLSLSTL GHVLNFLKVQ KIDFEKLKET LTIEQLKEQL TDIVEACHAK TLEQQKKTGR 1980
IELERGYATI PLKIDVPFHS SFLRGGVRMF REYLVKKIFP HQINVAKLRG KYIPNLTAKP 2040
FEISKEYFQN VYDLTGSQRI KKILQNWDEY ESS
2074Fasta Sequence
>Q9UUG0|fas1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MVEAEQVHQSLRSLVLSYAHFSPSILIPASQYLLAAQLRDEFLSLHPAPSAESVEKEGAELEFEHELHLLAGFLGLIAAKEEETPGQYTQLLRIITLEFERTFLAGNEVHAVVHSLGLNIPAQKDVVRFYYHSCALIGQTTKFHGSALLDESSVKLAAIFGGQGYEDYFDELIELYEVYAPFAAELIQVLSKHLFTLSQNEQASKVYSKGLNVLDWLAGERPERDYLVSAPVSLPLVGLTQLVHFSVTAQILGLNPGELASRFSAASGHSQGIVVAAAVSASTDSASFMENAKVALTTLFWIGVRSQQTFPTTTLPPSVVADSLASSEGNPTPMLAVRDLPIETLNKHIETTNTHLPEDRKVSLSLVNGPRSFVVSGPARSLYGLNLSLRKEKADGQNQSRIPHSKRKLRFINRFLSISVPFHSPYLAPVRSLLEKDLQGLQFSALKVPVYSTDDAGDLRFEQPSKLLLALAVMITEKVVHWEEACGFPDVTHIIDFGPGGISGVGSLTRANKDGQGVRVIVADSFESLDMGAKFEIFDRDAKSIEFAPNWVKLYSPKLVKNKLGRVYVDTRLSRMLGLPPLWVAGMTPTSVPWQFCSAIAKAGFTYELAGGGYFDPKMMREAIHKLSLNIPPGAGICVNVIYINPRTYAWQIPLIRDMVAEGYPIRGVTIAAGIPSLEVANELISTLGVQYLCLKPGSVEAVNAVISIAKANPTFPIVLQWTGGRAGGHHSFEDFHSPILLTYSAIRRCDNIVLIAGSGFGGADDTEPYLTGEWSAAFKLPPMPFDGILFGSRLMVAKEAHTSLAAKEAIVAAKGVDDSEWEKTYDGPTGGIVTVLSELGEPIHKLATRGIMFWKELDDTIFSLPRPKRLPALLAKKQYIIKRLNDDFQKVYFPAHIVEQVSPEKFKFEAVDSVEDMTYAELLYRAIDLMYVTKEKRWIDVTLRTFTGKLMRRIEERFTQDVGKTTLIENFEDLNDPYPVAARFLDAYPEASTQDLNTQDAQFFYSLCSNPFQKPVPFIPAIDDTFEFYFKKDSLWQSEDLAAVVGEDVGRVAILQGPMAAKHSTKVNEPAKELLDGINETHIQHFIKKFYAGDEKKIPIVEYFGGVPPVNVSHKSLESVSVTEEAGSKVYKLPEIGSNSALPSKKLWFELLAGPEYTWFRAIFTTQRVAKGWKLEHNPVRRIFAPRYGQRAVVKGKDNDTVVELYETQSGNYVLAARLSYDGETIVVSMFENRNALKKEVHLDFLFKYEPSAGYSPVSEILDGRNDRIKHFYWALWFGEEPYPENASITDTFTGPEVTVTGNMIEDFCRTVGNHNEAYTKRAIRKRMAPMDFAIVVGWQAITKAIFPKAIDGDLLRLVHLSNSFRMVGSHSLMEGDKVTTSASIIAILNNDSGKTVTVKGTVYRDGKEVIEVISRFLYRGTFTDFENTFEHTQETPMQLTLATPKDVAVLQSKSWFQLLDPSQDLSGSILTFRLNSYVRFKDQKVKSSVETKGIVLSELPSKAIIQVASVDFQSVDCHGNPVIEFLKRNGKPIEQPVEFENGGYSVIQVMDEGYSPVFVTPPTNSPYAEVSGDYNPIHVSPTFAAFVELPGTHGITHGMYTSAAARRFVETYAAQNVPERVKHYEVTFVNMVLPNTELITKLSHTGMINGRKIIKVEVLNQETSEPVLVGTAEVEQPVSAYVFTGQGSQEQGMGMDLYASSPVARKIWDSADKHFLTNYGFSIIDIVKHNPHSITIHFGGSKGKKIRDNYMAMAYEKLMEDGTSKVVPVFETITKDSTSFSFTHPSGLLSATQFTQPALTLMEKSAFEDMRSKGLVQNDCAFAGHSLGEYSALSAMGDVLSIEALVDLVFLRGLTMQNAVHRDELGRSDYGMVAANPSRVSASFTDAALRFIVDHIGQQTNLLLEIVNYNVENQQYVVSGNLLSLSTLGHVLNFLKVQKIDFEKLKETLTIEQLKEQLTDIVEACHAKTLEQQKKTGRIELERGYATIPLKIDVPFHSSFLRGGVRMFREYLVKKIFPHQINVAKLRGKYIPNLTAKPFEISKEYFQNVYDLTGSQRIKKILQNWDEYESS
|
| Keyword |
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0378--Hydrolase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0456--Lyase
KW-0511--Multifunctional enzyme
KW-0520--NAD
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR001227--Ac_transferase_dom
IPR014043--Acyl_transferase
IPR016035--Acyl_Trfase/lysoPLipase
IPR013785--Aldolase_TIM
IPR013565--DUF1729
IPR003965--Fatty_acid_synthase
IPR016452--Fatty_acid_Synthase_bsu_fun
IPR029069--HotDog_dom
IPR002539--MaoC_dom
IPR032088--SAT
|
| PROSITE |
|
| Pfam |
PF00698--Acyl_transf_1
PF08354--DUF1729
PF01575--MaoC_dehydratas
PF16073--SAT
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005835--C:fatty acid synthase complex
GO:0047451--F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0004317--F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004313--F:[acyl-carrier-protein] S-acetyltransferase activity
GO:0004314--F:[acyl-carrier-protein] S-malonyltransferase activity
GO:0004318--F:enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0004312--F:fatty acid synthase activity
GO:0004321--F:fatty-acyl-CoA synthase activity
GO:0016295--F:myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0004320--F:oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296--F:palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0006633--P:fatty acid biosynthetic process
|
