| Tag |
Content |
| dbPAF ID |
dbPAF-0040911 |
| Uniprot Accession |
Q9UUE1; PYC_SCHPO; P78822;
|
| Genbank Protein ID |
NP_595900.1;
|
| Genbank Nucleotide ID |
NM_001021807.2;
|
| Protein Name |
Pyruvate carboxylase |
| Protein Synonyms/Alias |
Pyruvic carboxylase;PCB; |
| Gene Name |
pyr1 |
| Gene Synonyms/Alias |
SPBC17G9.11c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.Functional Description
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MTSKYDALLH NQSTNTNPFS KLQDRSSLLG EKFTKVLVAN RSEIAIRVFR TAHELSMHTV 60
AIYSYEDRLS MHRQKADESY PIGKVGQYSP VGAYLAIDEI VSIAKRTGAN LVHPGYGFLS 120
ENAEFARKVN EAGMQFVGPS PEVIDSLGDK TKARAIAIRC GVPVVPGTPG PVEHYEEAEA 180
FVKEYGLPVI IKAAMGGGGR GMRVVRSADT LKESFERARS EALASFGDGT VFIERFLDKP 240
KHIEIQLMAD KAGNVIHLHE RDCSVQRRHQ KVVEIAPAKD LDPKIRQALY DDAIKIAKEV 300
KYCNAGTAEF LLDQKGRHYF IEINPRIQVE HTITEEITGV DIVSAQLHVA AGFTLPEIGL 360
TQDKISTRGF AIQCRVTTED PNNGFAPDIG KIEVYRSAGG NGVRLDGANG FAGSVITPHY 420
DSMLVKCTCH DATYEYTRRK MIRSLIEFRV RGVKTNIPFV LRLLMHDTFI QGNCWTTFID 480
DTPELFQLYR SRNRAQKLLA YLGDLAVNGS SIKGQNGEPA LKSEIVMPVL LDSTGNQIDV 540
SHPSEKGWRK LLLDNGPAAF AKAVRNHKRG LIMDTTWRDA HQSLLATRVR TIDLVNIAPY 600
TSHALASAYS LEMWGGATFD VSMRFLHECP WDRLRRLRKL VPNIPFQMLL RGANGLCYSS 660
LPDNVIYFFC EQAKKNGIDI FRVFDALNDV NNLSLGIDAA KRAGGVVEAT MCYSGDMLNP 720
KKKYNLDYYV NLVDKMVEMG IHILGIKDMA GVMKPKAARL LISAIREKHP ELPIHVHTHD 780
SAGTAVASMA AALEAGADVV DVATDSMSGL TSQPSFGAVL ASVDGTDKQL EFDNNQLREI 840
DSYWAQMRLL YSPFESEIKG TDSDVYNHEI PGGQLTNLKF QATSLGLGTQ WAETKKAYIE 900
ANKLLGDIIK VTPTSKVVGD LAQFMVQNKL SAEDVENRAT TLDFPASVLD FFQGLMGQPY 960
GGFPEPLRTN VLKGRRQPLT DRPGKFLPAA DFDAIRKLLS EKFGVSSDCD IAAYTQFPGV 1020
FEEYRQFVDR YGDLTTVPTK FFLSRPEMNE EMHVEIDQGK TLIVKFVALG PLNPRTGQRE 1080
VYFELNGENR HVTVEDKKAA IETVTRPRAD PGNPGHVAAP MSGTIVEIRV KEGAKVKKGD 1140
IIAVLSAMKM EIVISAPHSG VLKSLAVVQG DSVNGGDLCA VLEHE
1186Fasta Sequence
>Q9UUE1|pyr1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MTSKYDALLHNQSTNTNPFSKLQDRSSLLGEKFTKVLVANRSEIAIRVFRTAHELSMHTVAIYSYEDRLSMHRQKADESYPIGKVGQYSPVGAYLAIDEIVSIAKRTGANLVHPGYGFLSENAEFARKVNEAGMQFVGPSPEVIDSLGDKTKARAIAIRCGVPVVPGTPGPVEHYEEAEAFVKEYGLPVIIKAAMGGGGRGMRVVRSADTLKESFERARSEALASFGDGTVFIERFLDKPKHIEIQLMADKAGNVIHLHERDCSVQRRHQKVVEIAPAKDLDPKIRQALYDDAIKIAKEVKYCNAGTAEFLLDQKGRHYFIEINPRIQVEHTITEEITGVDIVSAQLHVAAGFTLPEIGLTQDKISTRGFAIQCRVTTEDPNNGFAPDIGKIEVYRSAGGNGVRLDGANGFAGSVITPHYDSMLVKCTCHDATYEYTRRKMIRSLIEFRVRGVKTNIPFVLRLLMHDTFIQGNCWTTFIDDTPELFQLYRSRNRAQKLLAYLGDLAVNGSSIKGQNGEPALKSEIVMPVLLDSTGNQIDVSHPSEKGWRKLLLDNGPAAFAKAVRNHKRGLIMDTTWRDAHQSLLATRVRTIDLVNIAPYTSHALASAYSLEMWGGATFDVSMRFLHECPWDRLRRLRKLVPNIPFQMLLRGANGLCYSSLPDNVIYFFCEQAKKNGIDIFRVFDALNDVNNLSLGIDAAKRAGGVVEATMCYSGDMLNPKKKYNLDYYVNLVDKMVEMGIHILGIKDMAGVMKPKAARLLISAIREKHPELPIHVHTHDSAGTAVASMAAALEAGADVVDVATDSMSGLTSQPSFGAVLASVDGTDKQLEFDNNQLREIDSYWAQMRLLYSPFESEIKGTDSDVYNHEIPGGQLTNLKFQATSLGLGTQWAETKKAYIEANKLLGDIIKVTPTSKVVGDLAQFMVQNKLSAEDVENRATTLDFPASVLDFFQGLMGQPYGGFPEPLRTNVLKGRRQPLTDRPGKFLPAADFDAIRKLLSEKFGVSSDCDIAAYTQFPGVFEEYRQFVDRYGDLTTVPTKFFLSRPEMNEEMHVEIDQGKTLIVKFVALGPLNPRTGQREVYFELNGENRHVTVEDKKAAIETVTRPRADPGNPGHVAAPMSGTIVEIRVKEGAKVKKGDIIAVLSAMKMEIVISAPHSGVLKSLAVVQGDSVNGGDLCAVLEHE
|
| Keyword |
KW-0067--ATP-binding
KW-0092--Biotin
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0312--Gluconeogenesis
KW-0436--Ligase
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc
|
| Interpro |
IPR013785--Aldolase_TIM
IPR011761--ATP-grasp
IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR005481--BC-like_N
IPR001882--Biotin_BS
IPR011764--Biotin_carboxylation_dom
IPR005482--Biotin_COase_C
IPR000089--Biotin_lipoyl
IPR003379--Carboxylase_cons_dom
IPR005479--CbamoylP_synth_lsu-like_ATP-bd
IPR009057--Homeodomain-like
IPR016185--PreATP-grasp_dom
IPR000891--PYR_CT
IPR005930--Pyruv_COase
IPR011054--Rudment_hybrid_motif
IPR011053--Single_hybrid_motif
|
| PROSITE |
PS50975--ATP_GRASP
PS50979--BC
PS00188--BIOTIN
PS50968--BIOTINYL_LIPOYL
PS00867--CPSASE_2
PS50991--PYR_CT
|
| Pfam |
PF02785--Biotin_carb_C
PF00364--Biotin_lipoyl
PF00289--CPSase_L_chain
PF02786--CPSase_L_D2
PF00682--HMGL-like
PF02436--PYC_OADA
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0009374--F:biotin binding
GO:0004075--F:biotin carboxylase activity
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0004736--F:pyruvate carboxylase activity
GO:0006091--P:generation of precursor metabolites and energy
GO:0006094--P:gluconeogenesis
GO:0006090--P:pyruvate metabolic process
|
