| Tag |
Content |
| dbPAF ID |
dbPAF-0040910 |
| Uniprot Accession |
Q9UUD1; SREBP_SCHPO;
|
| Genbank Protein ID |
NP_595694.1;
|
| Genbank Nucleotide ID |
NM_001021591.2;
|
| Protein Name |
Sterol regulatory element-binding protein 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
sre1 |
| Gene Synonyms/Alias |
SPBC19C2.09; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen.Functional Description
Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MQSSIPSVSV SVASPAMETP TKASPDSKSP NSVGAIPSSS PLASSTKAST STPFVENCSN 60
LLCDLASIVE DSPPTLTNTS LSPHSFSLSD MESSMSNWLN PFAFDNTMNS APPLFTSTNM 120
GSPNSLENST NPLLSNCGSP NSFQNETFTG PSLNEFDADD KIQRQMKILH SVDTIDPSTV 180
QNYPSADMSN PEVKLKTEEI ITPMDTTCKP EPSAKKIKLS PSSEDSCSIP ETLPFSAPKS 240
RGSLSPSETP DFVAGPGGKP KKTAHNMIEK RYRTNLNDRI CELRDAVPSL RAAAALRCGN 300
SLDDEDLGGL TPARKLNKGT ILAKATEYIR HLEAKNKELQ KTNKQLSDRL AFYEDPSMAP 360
PSNDTRAVNS VNVVSSSDYS VHQSSRPNLT QRAFTSPTLN TMGRTALNGM VGLGLFNYFG 420
NDSSQSVYGL FALPPFLMSP FTGTVLFNML KIGVVLLGLF YLLHDNSLFK GFKGEKKSKV 480
STRSSMSPSS ILFRKTVFEK YCLLDHSTST ISLFFGLLIF TLKSAYGYLT HRLSALYTSS 540
ENWVYSEQQL AEVRNMEKLL DAQLMGGDAK VDRLRLLMVF ASSFSLPPSS HTCALQAMYC 600
QLIFSNTSVP SAIVSKCVAF FWNAAKKQHS KSSVHAELRE LPECTANLIE NSHADDVFSP 660
NMVERLWVLA KCTRDSAQMS DSIISSLSDV LVLSPLEVLA SWYAADLLDA LLMESLSRKV 720
EISEIEEIIS LCPKNSSIIR HALLAKLVLF PENTADSLNE VLAAYKNTLD LCSQDKRKQS 780
SVLKINLSKL FTLHSCLSLA LQRLGYGDVS KRMYQEIFVP DSDADITPLS FIISWTALNT 840
FAPICTSPKE NDVVEKMAMY VRTAIGTLKI QDLKLSRKLI NSCIDIGSRL QEDLGYVSSA 900
901Fasta Sequence
>Q9UUD1|sre1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MQSSIPSVSVSVASPAMETPTKASPDSKSPNSVGAIPSSSPLASSTKASTSTPFVENCSNLLCDLASIVEDSPPTLTNTSLSPHSFSLSDMESSMSNWLNPFAFDNTMNSAPPLFTSTNMGSPNSLENSTNPLLSNCGSPNSFQNETFTGPSLNEFDADDKIQRQMKILHSVDTIDPSTVQNYPSADMSNPEVKLKTEEIITPMDTTCKPEPSAKKIKLSPSSEDSCSIPETLPFSAPKSRGSLSPSETPDFVAGPGGKPKKTAHNMIEKRYRTNLNDRICELRDAVPSLRAAAALRCGNSLDDEDLGGLTPARKLNKGTILAKATEYIRHLEAKNKELQKTNKQLSDRLAFYEDPSMAPPSNDTRAVNSVNVVSSSDYSVHQSSRPNLTQRAFTSPTLNTMGRTALNGMVGLGLFNYFGNDSSQSVYGLFALPPFLMSPFTGTVLFNMLKIGVVLLGLFYLLHDNSLFKGFKGEKKSKVSTRSSMSPSSILFRKTVFEKYCLLDHSTSTISLFFGLLIFTLKSAYGYLTHRLSALYTSSENWVYSEQQLAEVRNMEKLLDAQLMGGDAKVDRLRLLMVFASSFSLPPSSHTCALQAMYCQLIFSNTSVPSAIVSKCVAFFWNAAKKQHSKSSVHAELRELPECTANLIENSHADDVFSPNMVERLWVLAKCTRDSAQMSDSIISSLSDVLVLSPLEVLASWYAADLLDALLMESLSRKVEISEIEEIISLCPKNSSIIRHALLAKLVLFPENTADSLNEVLAAYKNTLDLCSQDKRKQSSVLKINLSKLFTLHSCLSLALQRLGYGDVSKRMYQEIFVPDSDADITPLSFIISWTALNTFAPICTSPKENDVVEKMAMYVRTAIGTLKIQDLKLSRKLINSCIDIGSRLQEDLGYVSSA
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0753--Steroid metabolism
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR011598--bHLH_dom
IPR019006--DUF2014
|
| PROSITE |
PS50888--BHLH
|
| Pfam |
PF09427--DUF2014
PF00010--HLH
|
| Gene Ontology |
GO:0071458--C:integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0032936--C:SREBP-SCAP complex
GO:0003677--F:DNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0071456--P:cellular response to hypoxia
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0072592--P:oxygen metabolic process
GO:0035961--P:positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
GO:1900413--P:positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0061419--P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0010630--P:regulation of transcription, start site selection
GO:0032933--P:SREBP signaling pathway
GO:0008202--P:steroid metabolic process
GO:0006366--P:transcription from RNA polymerase II promoter
|
