dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0040908
Uniprot Accession Q9UUB6; UBLH2_SCHPO;
Genbank Protein ID NP_595456.1;
Genbank Nucleotide ID NM_001021366.2;
Protein Name Ubiquitin carboxyl-terminal hydrolase 2
Protein Synonyms/Alias
Gene Name uch2
Gene Synonyms/Alias SPBC409.06;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
233LLTREDLTDEEKAASdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)
MSWTTIESDA GVFTDLIENL GVKDVEVDEL YSLDVDSLRQ FPDIYGIIFL FKWNSKVDKP 60
DGTMDYDSMD NIFFAKQVIN NACATQALLS VLLNHSDEID LGTTLSEFKD FSKTLPPELK 120
GEALGNSEHI RCCHNSFARS DPFISEEVRA ATDEDEVYHF IAYTNINNVF YELDGLQAAP 180
INHGSCTKEE FAEKAVSVIQ ARIANYDPAE IRFNLMVICK DKKASLLTRE DLTDEEKAAS 240
IAVEDEKRLR WKRENQLRRH NFVGLFVELS KLLVKDRIDK NTWNSTLETA KAKYASQKRP 300
301
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

PROSITE
Pfam

PF01088--Peptidase_C12

Gene Ontology

GO:0005737--C:cytoplasm
GO:0034399--C:nuclear periphery
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0008242--F:omega peptidase activity
GO:0004843--F:ubiquitin-specific protease activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process