dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0040885 | ||||||||||||
| Uniprot Accession | Q9UTK7; DSC2_SCHPO; | ||||||||||||
| Genbank Protein ID | NP_594090.1; | ||||||||||||
| Genbank Nucleotide ID | NM_001019514.2; | ||||||||||||
| Protein Name | DSC E3 ubiquitin ligase complex subunit 2 | ||||||||||||
| Protein Synonyms/Alias | Defective for SREBP cleavage protein 2;UBA domain-containing protein 14; | ||||||||||||
| Gene Name | dsc2 | ||||||||||||
| Gene Synonyms/Alias | ucp14;SPAC1486.02c; | ||||||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||||||
| NCBI Taxa ID | 284812 | ||||||||||||
| Functional Description (View all) |
Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MSSANIVPSN MGITKFLLLT ISTSSVVAGV FALKPFFHIN FGLHLLSHYQ YWRILLWQFI 60 YWNSTEVFQA LFIIYQARDV ERLLGSHRFA SFCVYMFILG MFVTPIFSFL YSLLFKNLDY 120 IQPGPTFLIF AILYQYYYIV PSTVFVRLFN IKFTDKFQMV IPMIGLAFSH FPSTFINAFL 180 GWTMGMFYHL SLLPGTSWRL PIRFVKPALS PTHVFIRPPY SDMQNASTFN PETLFALPTG 240 LDAERTENEN QVENPVSNAD ANDSPTRQNA RATAIASSSN TAASFRNRQQ ISHPPLGRTS 300 SSSVLPTGPA SQLYDMLSGR SERPELGNIR EEDINTVQTI MQTSRAQAIQ ALSQTNDVQR 360 AVELLLEQTA DY 373 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | |||||||||||||
| PROSITE | |||||||||||||
| Pfam | |||||||||||||
| Gene Ontology | GO:0000139--C:Golgi membrane |