dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0040866
Uniprot Accession Q9UT53; NMAH_SCHPO;
Genbank Protein ID NP_592856.2;
Genbank Nucleotide ID NM_001018257.2;
Protein Name Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
Protein Synonyms/Alias
Gene Name SPAC806.06c
Gene Synonyms/Alias
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
36IQYSDEFSPDEDWLNdbPTM 3.0;UniProt18257517; 16381945; 23193290
85KREADVASLGEVMDLdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
Sequence
(Fasta)		MHTMNGDNFA NSFPKNPLLS RNSSSSNVIQ YSDEFSPDED WLNEHAAKEH EERIRRPSVN 60
RAWQKNSTSG GPSVSLEKRE ADVASLGEVM DLEEVPRGIT RQARQLNEYI FPKHRFRNHL 120
VDEGKIPLVL VACGSFSPIT YLHLRMFEMA TDTIQEQTNM ELVAGYFSPV NDHYKKEGLA 180
PAYHRVRMCE LACERTSSWL MVDAWESLQP SYTCTARVLD HFDEEINQKR GGITLSDGTK 240
RPCKIMLLAG GDLIASMGEP GVWSDKDLHH ILGKFGCCIV ERTGSDVWAF LLAHDIMFAY 300
RGNILVIKQL IYNDISSTKV RLFIRRGMSI RYLLPNSVIQ YIERYALYRD AEPVKTIFYQ 360
SPFVRMEP 369
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0520--NAD
KW-0547--Nucleotide-binding
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0662--Pyridine nucleotide biosynthesis
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR004821--Cyt_trans-like
IPR005248--NAMN_adtrnsfrase
IPR014729--Rossmann-like_a/b/a_fold
PROSITE
Pfam

PF01467--CTP_transf_like
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000309--F:nicotinamide-nucleotide adenylyltransferase activity
GO:0004515--F:nicotinate-nucleotide adenylyltransferase activity
GO:0009435--P:NAD biosynthetic process