dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0040846 | ||||||||||||
| Uniprot Accession | Q9USU8; NGG1_SCHPO; | ||||||||||||
| Genbank Protein ID | NP_595671.1; | ||||||||||||
| Genbank Nucleotide ID | NM_001021566.2; | ||||||||||||
| Protein Name | Chromatin-remodeling complexes subunit ngg1 | ||||||||||||
| Protein Synonyms/Alias | Kinesin-associated protein 1; | ||||||||||||
| Gene Name | ngg1 | ||||||||||||
| Gene Synonyms/Alias | ada3;kap1;SPBC28F2.10c; | ||||||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||||||
| NCBI Taxa ID | 284812 | ||||||||||||
| Functional Description (View all) |
Transcription regulator. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of a subset of genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MSSEQQNEAD SKPAVIPQCF KIENQYETFS RLSETSTPGV VPSVSTLWRL LFELQKMIEC 60 EPSCVEYFRQ RKEELESHVD SEIETSKDES SVNKVEEKVE EFKEDNVEQE IKQKRSLSES 120 PQESMLEKVS KKPKVSEAHN EEISPENVET IENELDLPVK GKDEQTTGLV YKNANDLLTG 180 SLLSFIVDDS FSYEQKKKLL CVDSFPTSDV RSLVAGTPAT DDFSHNKPNN QISISTFYSS 240 LDPYFRAFND DDIAFLKKGF DVSSSYNIPP LGERYYDLTP EDEMTNLCAN SIYQNLQTSA 300 QGSLEAFNEA DTVSEEVRCG PLTERLMASL IPCYTQNDEE QKPSIAVGEF AETDSGSEKS 360 KIGTSIDGIE SGNNEYTEQP DIQESSLSIC EDRLRYTLKQ LGILYDGDVD WSKRQDDEIS 420 ATLRSLNARL KVVSDENEKM RNALLQMLPE EMAFQEFQNV MDDLDKQIEQ AYVKRNRSLK 480 VKKKRIVTDK IGSSATSGSF PVIKSLMDKR SMWLEKLQPL FQDKLTQHLG SPTSIFNDLS 540 DHTTSNYSTS V 552 |
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| Keyword | KW-0156--Chromatin regulator |
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| Interpro | IPR019340--Histone_AcTrfase_su3 |
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| PROSITE | |||||||||||||
| Pfam | PF10198--Ada3 |
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| Gene Ontology | GO:0000790--C:nuclear chromatin |