dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0040842 | ||||||||||||
| Uniprot Accession | Q9UST7; SFC3_SCHPO; | ||||||||||||
| Genbank Protein ID | NP_596127.1; | ||||||||||||
| Genbank Nucleotide ID | NM_001022045.2; | ||||||||||||
| Protein Name | Transcription factor tau subunit sfc3 | ||||||||||||
| Protein Synonyms/Alias | TFIIIC subunit sfc3;Transcription factor C subunit 3; | ||||||||||||
| Gene Name | sfc3 | ||||||||||||
| Gene Synonyms/Alias | tfc3;SPBC336.07; | ||||||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||||||
| NCBI Taxa ID | 284812 | ||||||||||||
| Functional Description (View all) |
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc6 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MDSLIRHCSE EIALDGSSGC SIDRLWEFAA NFFFRQGIVQ NLDDNYKTFV WPLILKEDGI 60 EVWIEDEDAT GLRSKMQEIP WNYQDITIEL RARIRLFASE DRQWLTLTYK TKTDSKIQPL 120 AFELLSCISR YRQEGVDRIQ LCKETKQEPR SVYGRIQALE DASLISKVAI NRSRAQTALL 180 VLKRFESENS TINETVAQVS GKQIYNTEKI RSNICDAVQS SRNGICRHVD ARAMVNLNHS 240 RWERRYYARQ VTYLHNNGYL RKCLTFVPNS PERCIRCLQF IKPYISSLDA TEDDVDFTEV 300 DDIPEDDELE EEEPLLPSKE EFDASFLQPL ADVGPTLPQW SRFRPLEFQC FVLIRNAGFH 360 GVITLQILSG LTGIRFNKPL FKLLGSLVEH RSSVPNHLSH MSITRFEDKT KKSRQYRYFT 420 LQSQLNRLIR DGIPAETISK LLPHVHSLAG EFSPIDSSLF LNSLHHKGNM ESNAEVSPDG 480 MTLLPRKRGR PRKSANISVT SSPIRPSKNE NNLPSLAISP VSEGFIQNAT ISTPSTSSNL 540 SIAGSLTPSK TSRIYRGLAP LKNPEFNEDH VKKAEHLEPL LNVSSSVPSK NFTVSSPDHL 600 KYGNTSSLQV SDSQSSIDLD SSFHYPVSVD SQLSHSTGSL MANFSSPTKK RRLESVDFIF 660 LQRKGLILSY LVEQNGAFEI SRKMFEDLAD LKVRRNPETS RTVMDRRTFQ QTLEKLMQEK 720 KVRKLVIATN NGLGKLVRKD IVVQYDMKPD SPRFQQLRAQ ITTPEIEKQS TPEILKDVDV 780 DFLKRNTSLS RRKSMPAEIK RHKESSETKP VDKEEVKKNE KEKDDPMRLA QQLLESLAPD 840 FALHENTQQK SPVEKPKKLR KDRYASVEEF DYFSSTEHAS KRSVKRFKND FTSDEDETLI 900 RAVVITQIYY GGTNRLIKWE AVQKCFPNRD IYALTRRYLS IRQHTKFKGL QQFLSENWQQ 960 MYKDAVSRKD LMPYPDSVDD FDPTPYVKAS CRPYMISSSN LATTRLPRDL VDVYETYNIE 1020 VVKQETNFRE MIFDPSLSVA SKMNAYCDMP FTMPLSLNDK QNNEGDENCE KGQLFDAKST 1080 IKSIVAIPDA TYDARFSQER LMQYPEDILI AAHQELLDKR IITRVNSENS RLQPGRNFQF 1140 TEKFASSLKS PLPPFLLSQA KRFNKFLLEG FQNHKNHLFE ETSNSGTLAC ILDLLSQGKL 1200 QISIVGSKFN EYGLSEGYRT RLLEHDNINV TLVLSGKESE SKKNYGVTEK LATPPSHEPR 1260 LWLNGKCELI EMIWMNIEQS IVYQLLRKPG ILRSQLTNLL FPGLEPREFN EVLDYFIAAG 1320 AAIEKDGLYL NHNYLFKLT |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | |||||||||||||
| PROSITE | |||||||||||||
| Pfam | PF04182--B-block_TFIIIC |
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| Gene Ontology | GO:0005635--C:nuclear envelope |