| Tag |
Content |
| dbPAF ID |
dbPAF-0040834 |
| Uniprot Accession |
Q9USN7; HST2_SCHPO;
|
| Genbank Protein ID |
NP_588147.1;
|
| Genbank Nucleotide ID |
NM_001023136.2;
|
| Protein Name |
NAD-dependent protein deacetylase hst2 |
| Protein Synonyms/Alias |
Homologous to sir2 protein 2;Regulatory protein SIR2 homolog 2; |
| Gene Name |
hst2 |
| Gene Synonyms/Alias |
SPCC132.02; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.Functional Description
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MVKNTVKHVD SSKHLEKVAS LIKEGKVKKI CVMVGAGIST AAGIPDFRSP ETGIYNNLQR 60
FNLPYAEAVF DLSYFRKNPR PFYELAHELM PEKYRPTYTH YFIRLLHDKR LLQKCYTQNI 120
DTLERLAGVP DKALIEAHGS FQYSRCIECY EMAETEYVRA CIMQKQVPKC NSCKGLIKPM 180
IVFYGEGLPM RFFEHMEKDT KVCDMALVIG TSLLVHPFAD LPEIVPNKCQ RVLINREPAG 240
DFGERKKDIM ILGDCDSQVR ALCKLLGWSD ELEKLIDTSV ETLTEEISLL SVDSTIEKNA 300
SEQKKDDNSV NPFTKIEEKK KDEVTLLVSD DE
333Fasta Sequence
>Q9USN7|hst2|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MVKNTVKHVDSSKHLEKVASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIECYEMAETEYVRACIMQKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDTKVCDMALVIGTSLLVHPFADLPEIVPNKCQRVLINREPAGDFGERKKDIMILGDCDSQVRALCKLLGWSDELEKLIDTSVETLTEEISLLSVDSTIEKNASEQKKDDNSVNPFTKIEEKKKDEVTLLVSDDE
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031934--C:mating-type region heterochromatin
GO:0000790--C:nuclear chromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:1902377--C:nuclear rDNA heterochromatin
GO:1990707--C:nuclear subtelomeric heterochromatin
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0033558--F:protein deacetylase activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0030702--P:chromatin silencing at centromere
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0000183--P:chromatin silencing at rDNA
GO:1990619--P:histone H3-K9 deacetylation
GO:0006476--P:protein deacetylation
GO:0060303--P:regulation of nucleosome density
GO:1900392--P:regulation of transport by negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
