dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0040811 | ||||||||
| Uniprot Accession | Q9URY2; ALP7_SCHPO; Q9UU56; | ||||||||
| Genbank Protein ID | NP_594820.1; | ||||||||
| Genbank Nucleotide ID | NM_001020249.2; | ||||||||
| Protein Name | Microtubule protein alp7 | ||||||||
| Protein Synonyms/Alias | Altered polarity protein 7;Transforming acidic coiled-coil protein mia1;TACC protein mia1; | ||||||||
| Gene Name | alp7 | ||||||||
| Gene Synonyms/Alias | mia1;SPAC890.02c; | ||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||
| NCBI Taxa ID | 284812 | ||||||||
| Functional Description (View all) |
Required for bipolar spindle formation and proper chromosome segregation. Has an indirect role in connecting the kinetochores and the plus end of pole to chromosome microtubules by targeting alp14 to the spindle pole body. Involved in the emergence of large microtubule organizing centers (MTOC) in interphase cells. Attaches to the minus ends of microtubules and associates with the sites of microtubule attachment on the nuclear envelope. This leads to the stabilzation of the microtubule bundles. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSDIVSSSTD YSRRSPSSSS IGTNETDHTG FHEKRQGASS ESLIPPAQRS SEESMPAPKL 60 FPKLTSKPNP QLNLKDTLNK RVSDRLQALE LNKSFDFSGT PRPMHPISHP LSQHKTPEFK 120 HRKRNVESIL TPKNPSLFSS SNAASQRGSL NTAPSNFAYS HSSSLQTSAS SRPPVLSNGS 180 FPRQTNTAPL NPPVHLKDNI RNSATPSTSQ ADIPTQYPIN STQKQQAKYE AEIEGYKAKL 240 AGTYHEISVL QNTIVNVSGQ LIAVNDQLQQ LRSGKASTSP STKDTNMRLV EGHNEETLAL 300 QRGKYTQEEV DKLIQERMEK VAEDLHAQYS AKHTQKINAF KANYARKYEA TIQELQNQIG 360 TAPNAPKISN SNWEEERRAL KADNQTLQKQ LEKAIQERQD MSDFLNNFKA DMAKSDKLLM 420 QQQSQQTGDL ETLRLQLQAL QEELRVEREE RQQLIQMSED LVIAMDQLNL EQKS 475 |
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| Keyword | KW-0137--Centromere |
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| Interpro | IPR024312--Kinetocho_Slk19 |
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| PROSITE | |||||||||
| Pfam | PF12709--Kinetocho_Slk19 |
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| Gene Ontology | GO:0000778--C:condensed nuclear chromosome kinetochore |