dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0040807
Uniprot Accession Q9URX7; ANM1_SCHPO;
Genbank Protein ID NP_594825.2;
Genbank Nucleotide ID NM_001020254.3;
Protein Name Protein arginine N-methyltransferase 1
Protein Synonyms/Alias Type I protein arginine N-methyltransferase;Type I PRMT;
Gene Name rmt1
Gene Synonyms/Alias SPAC890.07c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in target proteins (By similarity). Asymmetrically dimethylates the polyadenylate-binding protein pab2, modulating pab2 oligomerization (PubMed:17213188).
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
19GLTAKDYYFDSYSHWdbPTM 3.0;UniProt18257517; 16381945; 23193290
176IEDADYKSEKIGFWDdbPTM 3.0;UniProt18257517; 16381945; 23193290
Sequence
(Fasta)
MPGNTKKSAD SGLTAKDYYF DSYSHWGIHE EMLKDDVRTL SYRDAIMQNP HLFRDKIVLD 60
VGCGTGILSM FCARAGAKHV YGVDMSEIIH KAVQIVEVNK LSDRITLIQG KMEEIQLPVE 120
KVDIIVSEWM GYFLLYESML DTVLVARDRY LAPDGLLFPD RAQIQLAAIE DADYKSEKIG 180
FWDDVYGFDF SPIKKDVWKE PLVDTVDRIA VNTNSCVILD LDLKTVKKED LAFSSPFEIT 240
ATRNDFVHAF LAWFDIEFSA CHKPIKFSTG PFSRYTHWKQ TVFYTHKDLT VKAGEYIRGT 300
ITCKPAEGNH RELDIDISYT FNPREPNREP VSEDLSYRMC 341
Keyword

KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase

Interpro

IPR025799--Arg_MeTrfase
IPR025714--Methyltranfer_dom
IPR029063--SAM-dependent_MTases

PROSITE

PS51678--SAM_MT_PRMT

Pfam

PF13847--Methyltransf_31

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0044020--F:histone methyltransferase activity (H4-R3 specific)
GO:0016274--F:protein-arginine N-methyltransferase activity
GO:0035242--F:protein-arginine omega-N asymmetric methyltransferase activity
GO:0034969--P:histone arginine methylation
GO:0043985--P:histone H4-R3 methylation
GO:0006406--P:mRNA export from nucleus
GO:0019919--P:peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0006355--P:regulation of transcription, DNA-templated