dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0039479
Uniprot Accession Q9P804; TRM1_SCHPO; O74566;
Genbank Protein ID NP_596547.1;
Genbank Nucleotide ID NM_001022468.2;
Protein Name tRNA (guanine(26)-N(2))-dimethyltransferase
Protein Synonyms/Alias tRNA 2,2-dimethylguanosine-26 methyltransferase;tRNA(guanine-26,N(2)-N(2)) methyltransferase;tRNA(m(2,2)G26)dimethyltransferase;
Gene Name trm1
Gene Synonyms/Alias SPBC25D12.05;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
93LDQNSELSQENLTKCcurated22817900
Sequence
(Fasta)
MYEANMLRLS QRISNAVNHF STAMMSGASA SLTEGSAIIP FSNPNEVFYN PVQQFNRDLS 60
VTAIRAWSET RSKKIVAKSH HRHQLLDQNS ELSQENLTKC DTTHDFEKNC SEKTDSTSAD 120
NIAGFTILEA LSATGLRSIR YAKELPNVKR ILANDLLENA VKTIEKNVNY NNVSDIVIPN 180
KGDANAVMHM NKFHYDVIDL DPYGSAAPFL DAAVQSVSKD GLLCITCTDS AVLAGNAYPE 240
KCFSNYGGSS LRSNFCHEQA VRHLLYAIAA SAAKYGRAIK PLLSLSIDFY FRVFVQIKAK 300
PVLVKNLQSQ SLLIYHCSGC GSFAEQPLGK TSPGRLPGTT KFSNASGPPV SANCEHCGYV 360
HHVGGPLWGG PLHDAEFLKK MRAIAEDLDP EVYGTKRRIL GMLALADEEL PDVPFYFVLS 420
QICSVLRSQS PPQNIFVSAL LNAGYRVSGS HAKSNAIKTN APWSFVWDVL RSWIKDHPVK 480
LENISKTSAG AAILEKTPTA EVDFTFRPDS EFASKKEGYT RYQMNPTENW GPKSKPGKRT 540
IAEVDSKS 549
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0819--tRNA processing
KW-0820--tRNA-binding

Interpro

IPR029063--SAM-dependent_MTases
IPR002905--Trm1

PROSITE

PS51626--SAM_MT_TRM1

Pfam
Gene Ontology

GO:0005739--C:mitochondrion
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0004809--F:tRNA (guanine-N2-)-methyltransferase activity
GO:0000049--F:tRNA binding
GO:0030488--P:tRNA methylation
GO:0002940--P:tRNA N2-guanine methylation