dbPAF Protein Information
| Tag | Content | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0039467 | ||||||||||||||||
| Uniprot Accession | Q9P7T4; MRC1_SCHPO; | ||||||||||||||||
| Genbank Protein ID | NP_594486.1; | ||||||||||||||||
| Genbank Nucleotide ID | NM_001019915.2; | ||||||||||||||||
| Protein Name | Mediator of replication checkpoint protein 1 | ||||||||||||||||
| Protein Synonyms/Alias | DNA replication checkpoint mediator mrc1; | ||||||||||||||||
| Gene Name | mrc1 | ||||||||||||||||
| Gene Synonyms/Alias | SPAC694.06c; | ||||||||||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||||||||||
| NCBI Taxa ID | 284812 | ||||||||||||||||
| Functional Description (View all) |
Component of the replisome and is required for rad3-dependent activation of the checkpoint kinase cds1 in response to replication fork arrest. Phosphorylation allows it to mediate the activation of cds1. | ||||||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 3
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| Sequence (Fasta) | MASLDENADE LHRMDSSDEA SINDDQEDIL DTPRTRVRKM LASVDMQLSS NAVSEASLDK 60 ESTVGNLENQ KNRSYSSEIY LHSDTNFLSN FDSAYERVRR LLNQQGGKSS LQKKEVEQIE 120 TQEGGDNAKG SPSSENKDSD RNSRLQQLIE KKRNALKKEQ EDLIQNSATS HSKSDNLDSE 180 SADDSDLADE SELSKKYTSD RKIRNASKKA LLELHRNTAR LTRETALKPE VVVKKKVTLR 240 EFFQKIGFKN DNQLENKAIS EEEANSTEPP NVEKEEPKPS VDRSTGIVNS EDIKELSVED 300 DSLELKEITP EALDIGQTSL FTTLNQTQVK KEDNKKFLLK EINAKLNEDD IDSELEIEVK 360 PKTTALDNIE KSKLSEENEH GIKGKLKQLA EIKLSKDGKP FENEFNIKSF NRNLVKRAAV 420 MAKLQRNQLE EELKAKGIYK PTIQGEKEEE EDPLERARND AEKIRQLEKA SGNASDEGEL 480 NDEEEVISSS NTPSTKAKTT NKVIISDVII EATQAEPKRR QKNSRVVFDE EDLTGDSHGS 540 SNMKISESDD ESNGDMIRDS FDRLSSESIK DSQKTEELHD SFGINDEVDQ STSLYVQNSQ 600 PSASQLTIVD ATYSQPPPRW ESSSRDDKTN TSSTQPSQVD SLVPTQLDST IPTQIDSVQR 660 NKDQDDEEIL EERRESRRDS KTFLSRTMLY NKDTGKADSA WASDLIEEQA IESDDEYAGI 720 GGLSDDGLSD SDAELEVQNM IDDETTIQKG EVASMAQFAK DQEMDRDEKL VKQLMKDVTT 780 GALRKRNRNG FAALDDSDDE DYSNLRREKL KELRRQKLLE DGNLNVLEGD KRKAFLATVE 840 DSLVSSKDNL TWLDATVEDS GVGSSDLGDE YLYSEQSLNH EEEEQMEEEL SEIFSSGGPN 900 VVDRVYLKKS STRHTSDNNS LEEVLPIFPG VRKLVSNSQS EKIGDLSNDN SMGAKSYKTP 960 IISSTQRPQG RKFRGLMNQS SKADISRTVD AGSIKVVPNS QSANPPRLLA SLNNYSDFD 1020 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR018564--Repl_chkpnt_MRC1_dom |
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| PROSITE | |||||||||||||||||
| Pfam | PF09444--MRC1 |
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| Gene Ontology | GO:0000790--C:nuclear chromatin |