dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0039461
Uniprot Accession Q9P7Q7; MAK1_SCHPO;
Genbank Protein ID NP_594687.1;
Genbank Nucleotide ID NM_001020116.2;
Protein Name Peroxide stress-activated histidine kinase mak1
Protein Synonyms/Alias His-Asp phosphorelay kinase phk3;Mcs4-associated kinase 1;
Gene Name mak1
Gene Synonyms/Alias phk3;SPAC1834.08;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
68LNRQHRNSFSFNNVScurated22817900
422LLSPWSRSPVASPSIdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
426WSRSPVASPSIQTDPcurated22817900
Sequence
(Fasta)		MRPPDDQINN NVGSNSHLEK LKEAMDHQLQ KSSKIVGSFT NSQNSSVGSV HSPILESPTS 60
LNRQHRNSFS FNNVSSPSLE DERLINFPRV NPNRLMTSKR PNELFKTSSM SSDCYSPQKS 120
RESLNSLCHS PAPSVSSCGN ALNNDNTSAS HSLTDEQPFE TDSSANLFKQ LQEKRNRTIG 180
NVYEMACLLV FKTGLMNFWK NIIDFFAQQF FSTQISVVEP RDLSDIYNTP WQLRCYYDGG 240
SHYDPYSNPI SVNDNLASSS YVTVVASDGS KGIIYKDPAS LKHEGDLLID SKVVQTVLER 300
ATLLVYTRKQ QHIVKNTKVH DNDYFSSIPN VDDIRSIKNS WKVFHDEKLN ELKKQVEISA 360
SAAQLNGLYP QKKRAFVSHF SQNRKPYSQS DISKAQSSSF SEEPSNIYDE YEQNLLSPWS 420
RSPVASPSIQ TDPNRNPFFQ NCLQESSFAT ESSTEKSASE SVSETAVNDD CKGMNFSGNR 480
RQEDHLNDFT SFPTETAVSI VHVPLMFPCS DQTSSRGRAP IAILSFKSNL VPYPENLIAS 540
IERLIPFIFS SYSNSQSVPL LPCPTQRHLL FNTSSTDNTK ELSMSASSEN SDCPHKEGEC 600
VGSFCNINAK GSSLNNIPKL PRFVPVPSEF FKKNQRSWVT LKKHRLLARL KSRISKKNSK 660
VNENLRFSLN DGENYSNETI TLKKDEIVLD KSKSYACCTS ESHKYVQGHC GGQAPPFPLL 720
KVIIDSIPVH VFTADPGSGK LTWVNRKTLL YCGLNMNEQI ELQFSRIHPD DLPNFLNDWK 780
SSLFSGSGFY HEIRLQRFDN VYRYFICRAV PLRDCTGSVL HFFGTMTDVH DQKLAERELQ 840
KQSAIAANEN SYRSLAEASP QIVFAANGKN GIIYANAQWL SYSGLSLESS LGLGFLSAVY 900
HADRKKCLLP ESLEGTFNNQ DESNGTKTFA AEIRFRSTDG HYRWHLVKSV CVNNSADTST 960
NLWLGTCTDI HDHKMLEEKL QESNIEAQRI VRSKMQYLSN MSHEIRTPLI GITGMVSFLL 1020
ETQMSAEQLS YARIIQQSAK SLLTVINDIL DLSKVRAGMM KLTSQRFSVR AMMEDANETL 1080
GTLAFSKGIE LNYTVDIDVP DIVFGDNMRM RQVALNVIGN AIKFTNVGEV FTRCSVEKID 1140
YSTNTVVLKW ECIDTGQGFN RDDQLQMFKP FSQVESSTLP RHGGSGLGLV ISKELVELHN 1200
GSMSCQSRRG VGTRFMWTAT FTMDKTPLKF EPPDGCCPVC FCPYEKSKQS TEDYYCADDG 1260
NDKSATNFVK LAVNKADPGR ESNRRKLESD KNVQSNKYVN PFASESEFCR CGASADPYTV 1320
LFWRLYRNKP SGIKLDKSAL AVVVSHTKYS SEAIGNMLQS IIDISSFKDI VRYGNTYEAF 1380
EELLENPMQS KVTHIILNLP DIEAYVLFVK SLQLCSLYKD TKFILVTSTR QKESLSKIFS 1440
DSEDCNSESI HYVLKLVKPS KFFPLFYSDS EEKGKIGALN DMTRKAAMEQ KADAETLRYN 1500
LAKSGFSVLL AEDNIINIKV ISRYLERIGV KFKVTMDGLQ CVEEWKREKP NFYSLILMDL 1560
QMPVMDGYQA CNEIRKYELE NDYPKVPIVA LSANALPHVV LSCKDSGFDS YLAKPITLQH 1620
LSLIISGILN YTNQSKLHK
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0902--Two-component regulatory system
Interpro

IPR011006--CheY-like_superfamily
IPR003594--HATPase_C
IPR005467--His_kinase_dom
IPR003661--HisK_dim/P
IPR001610--PAC
IPR000014--PAS
IPR000700--PAS-assoc_C
IPR013655--PAS_fold_3
IPR004358--Sig_transdc_His_kin-like_C
IPR001789--Sig_transdc_resp-reg_receiver
PROSITE

PS50109--HIS_KIN
PS50113--PAC
PS50112--PAS
PS50110--RESPONSE_REGULATORY
Pfam

PF02518--HATPase_c
PF00512--HisKA
PF08447--PAS_3
PF13188--PAS_8
PF00072--Response_reg
Gene Ontology

GO:0032153--C:cell division site
GO:0051286--C:cell tip
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0000155--F:phosphorelay sensor kinase activity
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0010515--P:negative regulation of induction of conjugation with cellular fusion
GO:0018106--P:peptidyl-histidine phosphorylation
GO:0000160--P:phosphorelay signal transduction system
GO:0023014--P:signal transduction by protein phosphorylation
GO:0031098--P:stress-activated protein kinase signaling cascade