dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0039432 |
| Uniprot Accession | Q9P795; AIR1_SCHPO; |
| Genbank Protein ID | NP_595383.2; |
| Genbank Nucleotide ID | NM_001021290.2; |
| Protein Name | Protein air1 |
| Protein Synonyms/Alias | |
| Gene Name | air1 |
| Gene Synonyms/Alias | SPBP35G2.08c; |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID | 284812 |
| Functional Description (View all) |
Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MDMTVSNQKA ESDDGSDIDD AALLQKINSL PIDQSITNSV SLEKHDFQGS DDHDSSTDLS 60 DSTLEDVEGS EWADVSRGRY FGSDPSESIV CHNCKGNGHI SKDCPHVLCT TCGAIDDHIS 120 VRCPWTKKCM NCGLLGHIAA RCSEPRKRGP RVCRTCHTDT HTSSTCPLIW RYYVEKEHPV 180 RIDVSEVRKF CYNCASDEHF GDDCTLPSRS NYPESTAFCE ANCPSGNDAS NKEFFETRRK 240 EFQLERREQN RNQKSSKQRP FHKPGNSLAS RLGSKPKSFK RKHSPPSEEN GNLSFHSSDG 300 RKFTKTSKKN RKRKW 316 |
| Keyword | KW-0181--Complete proteome |
| Interpro | IPR001878--Znf_CCHC |
| PROSITE | PS50158--ZF_CCHC |
| Pfam | PF00098--zf-CCHC |
| Gene Ontology | GO:0005730--C:nucleolus |