| Tag |
Content |
| dbPAF ID |
dbPAF-0039425 |
| Uniprot Accession |
Q9P780; NPL4_SCHPO;
|
| Genbank Protein ID |
NP_595883.2;
|
| Genbank Nucleotide ID |
NM_001021789.2;
|
| Protein Name |
Nuclear protein localization protein 4 |
| Protein Synonyms/Alias |
|
| Gene Name |
npl4 |
| Gene Synonyms/Alias |
SPBC1711.10c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).Functional Description
Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 106 | GAPKQVSTPDVSEKK | curated | 22817900 |
|
Sequence
(Fasta) | MILRFRSKRG MARAEFQPTD TLAMLSAKIL SDILKNDYSP ENVSLCQNES DQGVIFSNLN 60
DQTLQDAGLT HGQMLYLRLG TPNSDIASSN NEPALTVTGA PKQVSTPDVS EKKPSMPVIQ 120
DPIDDSLEKE DGLIRRSMTS LCRHGPKGMC DYCSPLEPYD ESYRQENKIK HLSFHAYLRK 180
INSNVNKYAS SQSFIPPLEE PSFTVKEKCP SGHPPWPAGI CTKCQPSTVM LNLQPFRVID 240
HIEFASPGIV DSFLNKWRQS GFQRIGYTYG HFEQYNNVPL GIKGVIEAIY EPPQVSEADG 300
VTLEEWADEA LVEQVATACG LRRIGIIFTD LTDDGSNSGK VLCKRHSDSY FLSSLEVYNS 360
ANFQTKFKNP CKWSRSGYFG SKFVTSVISG NLNGEIEVMS YQVSNIGTAL YQADLIQPSV 420
DPDRMLVKKE DQTRYVPDVL YRYTDKYGKQ VSENAKPAFP VSFLLVTLTD GFPEKPDPLF 480
SNNDTSIITT LESTDETGRL RQLAKLFDHN AIANGSLSNF SVLLAIAKLS ILGKDDLAAL 540
ASYATAPTEE NEKNLNSRES YQTLLAILYS SL
573Fasta Sequence
>Q9P780|npl4|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MILRFRSKRGMARAEFQPTDTLAMLSAKILSDILKNDYSPENVSLCQNESDQGVIFSNLNDQTLQDAGLTHGQMLYLRLGTPNSDIASSNNEPALTVTGAPKQVSTPDVSEKKPSMPVIQDPIDDSLEKEDGLIRRSMTSLCRHGPKGMCDYCSPLEPYDESYRQENKIKHLSFHAYLRKINSNVNKYASSQSFIPPLEEPSFTVKEKCPSGHPPWPAGICTKCQPSTVMLNLQPFRVIDHIEFASPGIVDSFLNKWRQSGFQRIGYTYGHFEQYNNVPLGIKGVIEAIYEPPQVSEADGVTLEEWADEALVEQVATACGLRRIGIIFTDLTDDGSNSGKVLCKRHSDSYFLSSLEVYNSANFQTKFKNPCKWSRSGYFGSKFVTSVISGNLNGEIEVMSYQVSNIGTALYQADLIQPSVDPDRMLVKKEDQTRYVPDVLYRYTDKYGKQVSENAKPAFPVSFLLVTLTDGFPEKPDPLFSNNDTSIITTLESTDETGRLRQLAKLFDHNAIANGSLSNFSVLLAIAKLSILGKDDLAALASYATAPTEENEKNLNSRESYQTLLAILYSSL
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0811--Translocation
KW-0813--Transport
|
| Interpro |
IPR007717--NPL4
IPR024682--Npl4_Ub-like_dom
IPR007716--NPL4_Zn-bd_put
IPR016563--PolyUb_recognition_cplx_Npl4
IPR029071--Ubiquitin-rel_dom
|
| PROSITE |
|
| Pfam |
PF05021--NPL4
PF11543--UN_NPL4
PF05020--zf-NPL4
|
| Gene Ontology |
GO:0036266--C:Cdc48p-Npl4p-Vms1p AAA ATPase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0031965--C:nuclear membrane
GO:0042175--C:nuclear outer membrane-endoplasmic reticulum membrane network
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:1990112--C:RQC complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0030433--P:ER-associated ubiquitin-dependent protein catabolic process
GO:0051028--P:mRNA transport
GO:0015031--P:protein transport
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
|
