dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0039411
Uniprot Accession Q9P6K7; ARC1_SCHPO;
Genbank Protein ID NP_594656.1;
Genbank Nucleotide ID NM_001020085.2;
Protein Name tRNA-aminoacylation cofactor arc1
Protein Synonyms/Alias
Gene Name SPAC30C2.04
Gene Synonyms/Alias
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Binds to tRNA and functions as a cofactor for the methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS). Forms a complex with MetRS and GluRS and increases their affinity for cognate tRNAs due to the presence of a tRNA binding domain in its middle and C-terminal part (By similarity).
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
276KEPPKAATPVPSMIDcurated22817900
360AMVFCASSPDKSVVEcurated22817900
Sequence
(Fasta)
MSFLWAKEFC VLKYPYKLFI THKFSYLLRF ETVTLNNIRS PQFYAKLTFS HHQPTVSGTM 60
STELKFISKY LQISIPETKE GPVSSLFKAV SEQKPELLGN TDFEKAQILE WTTKAFSPIE 120
TQSIVEQLDE FLKSSTFIAQ DSGISVADLA VYARIHSYIC GLSAKEGYKL NNVCRWFDFI 180
QHQESVMEAA NSMSMKLANI DLNAPKIQRP SVIKKDKKEK KEGKPSQEAS VKSVEKAPKG 240
LEGAKKEKQN KKEKKDKKDK KDKKEKAPKE PPKAATPVPS MIDFRIGFIE KAVKHPNADS 300
LYVSTIHCGD AEGPRTVCSG LVKYIPLEQM QQRKVIVVAN LKPVNMRSVK SQAMVFCASS 360
PDKSVVEFVL PPENAEIGDR LTFEGFDTEE PEAQLNPKRK IWEAIQPGFT SGEDLICGYK 420
DESGLHRLFV KGKKDLGFCK AQTVVNGTLS 451
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0820--tRNA-binding

Interpro

IPR010987--Glutathione-S-Trfase_C-like
IPR012340--NA-bd_OB-fold
IPR002547--tRNA-bd_dom

PROSITE

PS50886--TRBD

Pfam

PF01588--tRNA_bind

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0017102--C:methionyl glutamyl tRNA synthetase complex
GO:0004825--F:methionine-tRNA ligase activity
GO:0000049--F:tRNA binding
GO:0002181--P:cytoplasmic translation
GO:0006431--P:methionyl-tRNA aminoacylation
GO:0006418--P:tRNA aminoacylation for protein translation