dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0039398 | ||||||||
| Uniprot Accession | Q9P3W5; TEL2_SCHPO; | ||||||||
| Genbank Protein ID | NP_594697.1; | ||||||||
| Genbank Nucleotide ID | NM_001020125.2; | ||||||||
| Protein Name | DNA replication checkpoint protein tel2 | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | tel2 | ||||||||
| Gene Synonyms/Alias | SPAC458.03; | ||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||
| NCBI Taxa ID | 284812 | ||||||||
| Functional Description (View all) |
Component of the TORC1 and TORC2 complexes required for the regulation of the cellular respons to changes in available nutrients. Required for normal entry into S phase. Regulates activation of the DNA replication checkpoint. Required for efficient phosphorylation of mrc1, which is essential for the activation of cds1 kinase. Plays also an important role in genome stability. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MKSFASELSK PIQKPRLKEI LKELQHIGVP SPCNLRLYHE LISVIVPTFW NGKINSEIDF 60 LLAKCFSTLL GLKLLCVRLD NFVQEANLQN IHLVTVYLEL LEKAFECIDL DDNCKLIWES 120 TVLSDHQKQS LWTEFIFFLG NFKITNSMSA AMLTFKVYDD SKRLKASSMA DYIGVLSSKL 180 ACIISKPAVK TPEIYSKLFH YLLHSSNLKA FINPLIPLTQ KFCVQLQKLF ADLTVSDQML 240 FLNQLLLEHN TKYPTNFSYS TARDDRITGS LATLLRLNFS STHFLRLIEF YWGVPTNLII 300 KRVEVVCSSI SYKESDKKEL EKTVDSLFNI WSNAQFLRSY TLLAQESLTI YLLLFIPKLE 360 AKYLNNLSKS LMFSNAISCR LDSLDDDIRM HGMIMAEVIS TYSGVSLSNP LAFDVPIMKT 420 TKAKVLKSLS SLKDEFLPIE ILNDESVIAE TSIEKEETNV THLEKPVISK NDDLIRGDDL 480 EPYDFPDIDS EDTDDDPTVS RSKTHSPVYV QDLCKMLKDT ESFEKQRVAL ENASKLIKRK 540 SAFGTELRDH ADELLQTLIS LQNRFDLMNF DEMQMTAIVE LLLTCLDICG PVICTNLFVS 600 DYSMRQKILI LSCISLAASK FNDDDNERLF PSQLLPGNLH DQFYSPTIEK ISDELERKLV 660 FPVMSECKDY AEGPKFLQTR YISKQSEIES KKPLPKANRL SLKVDKSLFL LLTSGYMLAS 720 RKTAFIEPLF LVYYLKTLGI LFFETFTSKI EGANRMLREY VDVLNEVCRL RSDTPEVNEG 780 LLFSFLAILE ISSGRTLANE FGKHLLFFEA YTKFLFESPD QGEKVKSLSA AVLILFENKL 840 SEFRTLALEK LLDDSAPLVP ERFGLAGL 869 |
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| Keyword | KW-0131--Cell cycle |
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| Interpro | IPR019337--Telomere_length_regulation_dom |
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| PROSITE | |||||||||
| Pfam | PF10193--Telomere_reg-2 |
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| Gene Ontology | GO:0070209--C:ASTRA complex |