dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0039392
Uniprot Accession Q9P381; CDSH_SCHPO;
Genbank Protein ID NP_596416.1;
Genbank Nucleotide ID NM_001022335.2;
Protein Name Putative phosphatidate cytidylyltransferase
Protein Synonyms/Alias CDP-DAG synthase;CDP-DG synthase;CDP-diacylglycerol synthase;CDS;CDP-diglyceride pyrophosphorylase;CDP-diglyceride synthase;CTP:phosphatidate cytidylyltransferase;
Gene Name SPBC13A2.03
Gene Synonyms/Alias
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
12RTNKRNNSDKENGNVdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
Sequence
(Fasta)
MARKRTNKRN NSDKENGNVG VVQNKDSASS KTTEPARLTK HKSLARKPSQ NFITRTIWTF 60
LLLGIFFTAL AMGHFWVVLL VTIVQIGVYK EVIAIASVPS REKDLPWTRF INWYFLMTTL 120
YYAYGESIYA YFHHLFIMDS FMLPLVLHHR FISFMLYIIG FVLFVASLKK GNYKFQFSQF 180
CWTHMTLLLV VGQSHFMINN LFEGLFWFFV PVCYVVCNDV FAYLCGKMFG KHPLIQVSPK 240
KTVEGFLGGW ICTVVIGSLI SYVLMHFKYF ICPTRDLSTS AFSGLNCTPN SVFLPHTYTI 300
PAVFVDTFRL PETITLAPIY FHLAIFATFS SLIAPFGGFF ASGLKRAFKI KDFGASIPGH 360
GGLTDRMDCQ FLNGVFVYMY FQSFIAEKST SVADLLDTAV YSLTTTQQVQ LVEDLQNYLI 420
SHGKTSVQAI CSKLLQNSK
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0460--Magnesium
KW-0472--Membrane
KW-0548--Nucleotidyltransferase
KW-0594--Phospholipid biosynthesis
KW-1208--Phospholipid metabolism
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR000374--PC_trans
IPR016720--PC_Trfase_euk

PROSITE

PS01315--CDS

Pfam
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0004605--F:phosphatidate cytidylyltransferase activity
GO:0016024--P:CDP-diacylglycerol biosynthetic process
GO:0006655--P:phosphatidylglycerol biosynthetic process
GO:0006658--P:phosphatidylserine metabolic process