dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0037880
Uniprot Accession Q9HGQ2; TRM4A_SCHPO; Q9P3W7;
Genbank Protein ID NP_594695.3;
Genbank Nucleotide ID NM_001020123.2;
Protein Name Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4a
Protein Synonyms/Alias tRNA (cytosine-5-)-methyltransferase trm4a;
Gene Name trm4a
Gene Synonyms/Alias SPAC17D4.04;SPAC458.01;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Functions redundantly with trm4b to methylate cytosine to m5C at several positions (48, 49, 60, 61 and 62) in tRNA(Asp).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
54ILLKQKLTEQLPTTFdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
Sequence
(Fasta)
MGRKHYSSKK NRSKKGEFVN WDLIERKNEN FEKYYRLQKL VTEDDFILLK QKLTEQLPTT 60
FRITASIPHA TQVRDYFIEH YYPLIENART EDAKIPLPVS LPWYPDGMAF MLDISKEVIR 120
KSPHLKALQE FLVLETEAGD INRQESVSMV PPLLLNVESH HKVLDMCAAP GSKTAQLLEA 180
LHKPTKKEDI TTLLPSGIVI ANDSDNKRAH MLVHQIKRLN SPNVLIVNHD ASFLPNFHLS 240
SPDGKKFLKF DRILADVPCS GDGTFRKNIA LWNEWSLKTA LGLHATQIKI LMRGLQLLEK 300
GGRLVYSTCS LNPIENEAVV SAVLNATRGS VRLVDVSSEL PQLKRSQGVD NWVVCDSDLN 360
IYPSFDTLPK ELYEKMPPTL WPLPKKELAE LNIQNCLRIY PHFQNTGGFF VAVLEKYENL 420
TSSMKTAVDD NKVFLREQKL PSEQASKKRK QDTQETSSDS KLAEVKPKGK NGGNRFHELD 480
PFVYIKEDDQ ALEKIYKKFG IDEAIIKKNQ FFVRNVNGVP TKAIYISNDL FRNVIENNRN 540
RVKFVHGGLK IFVRQDFGSL SREIAEKNGT CVFRVQSDGA NLASHFIAES CLFHTTLSDL 600
FILLDHEAVT IDDFPEDSLF RKEYNHLDLG STLLHVDLAK EESVIKKQVY IPLWKSVRIC 660
NVLLSNSEKR TLKLQIEGPQ SSIHKHNT 689
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0819--tRNA processing
KW-0820--tRNA-binding

Interpro

IPR018314--Fmu/NOL1/Nop2p_CS
IPR001678--MeTrfase_RsmB/NOP2
IPR023267--RCMT
IPR023270--RCMT_NCL1
IPR029063--SAM-dependent_MTases

PROSITE

PS01153--NOL1_NOP2_SUN
PS51686--SAM_MT_RSMB_NOP

Pfam

PF01189--Nol1_Nop2_Fmu

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0016428--F:tRNA (cytosine-5-)-methyltransferase activity
GO:0000049--F:tRNA binding
GO:0030488--P:tRNA methylation