| Tag |
Content |
| dbPAF ID |
dbPAF-0037878 |
| Uniprot Accession |
Q9HGN7; SEC63_SCHPO;
|
| Genbank Protein ID |
NP_595985.1;
|
| Genbank Nucleotide ID |
NM_001021892.2;
|
| Protein Name |
Translocation protein sec63 |
| Protein Synonyms/Alias |
|
| Gene Name |
sec63 |
| Gene Synonyms/Alias |
SPBC36B7.03; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec63 may affect sec61-polypeptide interactions by increasing the affinity of targeting pathways for sec61 and/or by modifying sec61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation (By similarity).Functional Description
Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec63 may affect sec61-polypeptide interactions by increasing the affinity of targeting pathways for sec61 and/or by modifying sec61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSSEYKYDEQ GIFFPVFLLV GTSCCVLPLT YSTILGPSAS KEKKNVRDPF QKYRPKDLKV 60
QRKSIFRLRY IFLILGWLAI GFLSYKIANS RLKLNIWDPY EILGIAKGTS VDDVRRHYKR 120
LSIKFHPDKV RNMVNTTREE VEKHYIEITN AYRALTDDKT RENYALYGTP DVPQHISVGI 180
ALPKWISESE NSIYILGFYG LVFGIVLPYA VGKWWYGSRT YTRDHVHVDT VDEWFPKMET 240
SLTLDELLSL FASSKELTSL VPNEKNPKEY ILKLLFDHLN RKKTNNFNTH QILSQSDVVL 300
NALLSVATAF GFANPVDNVL KLWQHIVQAI PLDAPFPLLQ LPHLLMEDVK NLSIRNISSI 360
PQFLSLSEEQ TKDYLPNYSK NQLKEMREIA NGIPRISVVA AKVLVDDDEY ITVGAIANLI 420
LDLKCSYGTE VVPEVSTDGT ETATKKDEED AEKYHQSKDV VLGDVETLPY AWAPYFTQHH 480
KTAWWIYVVD PRQNRVIVPP FSITDIPKTL RTFRIPFQVP PVAGTFSFQL HIMSNSYVGE 540
DVISNLTMIV KDTSVLQEQL QEEAVSDLED NSDIDESANA GKDFSDDENI GSDEEDESEY 600
DPMDTDTSDG E
612Fasta Sequence
>Q9HGN7|sec63|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MSSEYKYDEQGIFFPVFLLVGTSCCVLPLTYSTILGPSASKEKKNVRDPFQKYRPKDLKVQRKSIFRLRYIFLILGWLAIGFLSYKIANSRLKLNIWDPYEILGIAKGTSVDDVRRHYKRLSIKFHPDKVRNMVNTTREEVEKHYIEITNAYRALTDDKTRENYALYGTPDVPQHISVGIALPKWISESENSIYILGFYGLVFGIVLPYAVGKWWYGSRTYTRDHVHVDTVDEWFPKMETSLTLDELLSLFASSKELTSLVPNEKNPKEYILKLLFDHLNRKKTNNFNTHQILSQSDVVLNALLSVATAFGFANPVDNVLKLWQHIVQAIPLDAPFPLLQLPHLLMEDVKNLSIRNISSIPQFLSLSEEQTKDYLPNYSKNQLKEMREIANGIPRISVVAAKVLVDDDEYITVGAIANLILDLKCSYGTEVVPEVSTDGTETATKKDEEDAEKYHQSKDVVLGDVETLPYAWAPYFTQHHKTAWWIYVVDPRQNRVIVPPFSITDIPKTLRTFRIPFQVPPVAGTFSFQLHIMSNSYVGEDVISNLTMIVKDTSVLQEQLQEEAVSDLEDNSDIDESANAGKDFSDDENIGSDEEDESEYDPMDTDTSDGE
|
| Keyword |
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR000008--C2_dom
IPR001623--DnaJ_domain
IPR014756--Ig_E-set
IPR004179--Sec63-dom
|
| PROSITE |
PS50076--DNAJ_2
|
| Pfam |
PF00226--DnaJ
PF02889--Sec63
|
| Gene Ontology |
GO:0005938--C:cell cortex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005635--C:nuclear envelope
GO:0005637--C:nuclear inner membrane
GO:0031207--C:Sec62/Sec63 complex
GO:0030544--F:Hsp70 protein binding
GO:0008565--F:protein transporter activity
GO:0006620--P:posttranslational protein targeting to membrane
GO:0031204--P:posttranslational protein targeting to membrane, translocation
GO:0006457--P:protein folding
GO:0006614--P:SRP-dependent cotranslational protein targeting to membrane
|
