dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0037866 | ||||||||
| Uniprot Accession | Q9HE05; UFD2_SCHPO; O60009; Q9P7A3; Q9UTT4; Q9UU63; | ||||||||
| Genbank Protein ID | NP_593630.1; | ||||||||
| Genbank Nucleotide ID | NM_001019061.2; | ||||||||
| Protein Name | Ubiquitin conjugation factor E4 | ||||||||
| Protein Synonyms/Alias | Ubiquitin fusion degradation protein 2;UB fusion protein 2; | ||||||||
| Gene Name | ufd2 | ||||||||
| Gene Synonyms/Alias | SPAC145.04;SPAC20H4.10; | ||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||
| NCBI Taxa ID | 284812 | ||||||||
| Functional Description (View all) |
E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSDLEKIRLK RLAKLQQTNS EANSSKEPKE SNIAPEPKKP DLKKRFIGSK ATTSNSEQKE 60 ISPPVTSGAP KHRLFSKDEW MHFITCQALN ITLSETDSSK YYLEGFKKDL EEEGSPLLFN 120 ENNVDSALLS RLSTTGNNTF SYLLQSWSFL YQYKKRLPKD ENQDFKIHYL SLLKSLLVSY 180 AGIVVMLPDT FNSETIDLAE VLIGAEGIPL EFLSEFVQRF EHENLDELFI PVLESLSLKI 240 GLMNVDTVQM NVMQIILQLV SLKPIALLLP KLPSWNPTNN AGEIEYKTFL GRISSLSVFT 300 QDVASRYFSN STERSAQNIS SSISSLKLTM STYQDVLFQI FNTLIRTSTS LRESVLDFFA 360 MVVNANHKRQ SIQVNHFDIT SDACMLNFSH VLSRLSEPFL DIGCSKIDRV QVEYFRRNPR 420 VDIKEETKLN ADQKASESFY SKPAEGSNNF ISDIFFLNLA FHHYGVNATF KALEQLVQSI 480 RDSEKLKERL ETEQQNMSGS FQATRLTAQL SRLDQRLDLD RSFVHCYEIM LTQTSDTSRS 540 FSFLNFVAIW LSRLADGQSS TYPKMPLSLP FNENAPEAFK CLPEYFIETI TDYMLSLFKT 600 SSSTLTLHSL EPLCEFCVSF LTQANYIKNP YLRAKLAEIL YFGVQTHVGR SELLLDVVRT 660 SKVATRWLLP ALMAFYIEIE STGQSTQFYD KFNIRFYICE VFRTIWKQPA YFGKLEQEQK 720 TNLPFFVKFV ALMLNDATYL LDEALLKLTE IHNLQSLLAD AISNSNSNQN VQESQSNLAA 780 AERQASTYCQ LGNETIFMLK LFTSSIPKAF CAVEIVDRLA AMLNYNLQAL CGPKCSNLKV 840 EDPTKYHFNA KTLLSIIFDV YLNLCNEPAF VEAVAHDGRS YSKEIFERAT SIMTKHNLKS 900 SFDIEAIKEF VNRVEAFRLQ EATEEEDMGD IPDYFLDPLM FTIMKDPVVL PRSGISIDRS 960 TIKAHLLSDA TDPFNRTPLT LDDVTPNDTL REEINTFLKS KRNKHSRNSE 1011 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR019474--Ub_conjug_fac_E4_core |
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| PROSITE | PS51698--U_BOX |
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| Pfam | |||||||||
| Gene Ontology | GO:0005737--C:cytoplasm |