dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0037863 | ||||||||||||
| Uniprot Accession | Q9HDY1; ASE1_SCHPO; | ||||||||||||
| Genbank Protein ID | NP_593523.1; | ||||||||||||
| Genbank Nucleotide ID | NM_001018957.2; | ||||||||||||
| Protein Name | Anaphase spindle elongation protein 1 | ||||||||||||
| Protein Synonyms/Alias | |||||||||||||
| Gene Name | ase1 | ||||||||||||
| Gene Synonyms/Alias | SPAPB1A10.09; | ||||||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||||||
| NCBI Taxa ID | 284812 | ||||||||||||
| Functional Description (View all) |
Required for anaphase spindle elongation and microtubule bundling in both interphase and mitosis. Has a role in spatial and temporal regulation of septation and cytokinesis and ensures equal partition of segregating sister chromatids. Ensures correct midzone positioning of protein kinase ark1. Acts as a regulatory component at cytokinesis checkpoint where it inhibits nuclear division when actomyosin ring formation is impaired. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MQTVMMDDIQ STDSIAEKDN HSNNESNFTW KAFREQVEKH FSKIERLHQV LGTDGDNSSL 60 FELFTTAMNA QLHEMEQCQK KLEDDCQQRI DSIRFLVSSL KLTDDTSSLK IESPLIQCLN 120 RLSMVEGQYM AQYDQKLSTI KEMYHKLESY CNRLGSPFVL PDFENSFLSD VSDAFTESLR 180 GRINEAEKEI DARLEVINSF EEEILGLWSE LGVEPADVPQ YEQLLESHTN RPNDVYVTQE 240 LIDQLCKQKE VFSAEKEKRS DHLKSIQSEV SNLWNKLQVS PNEQSQFGDS SNINQENISL 300 WETELEKLHQ LKKEHLPIFL EDCRQQILQL WDSLFYSEEQ RKSFTPMYED IITEQVLTAH 360 ENYIKQLEAE VSANKSFLSL INRYASLIEG KKELEASSND ASRLTQRGRR DPGLLLREEK 420 IRKRLSRELP KVQSLLIPEI TAWEERNGRT FLFYDEPLLK ICQEATQPKS LYRSASAAAN 480 RPKTATTTDS VNRTPSQRGR VAVPSTPSVR SASRAMTSPR TPLPRVKNTQ NPSRSISAEP 540 PSATSTANRR HPTANRIDIN ARLNSASRSR SANMIRQGAN GSDSNMSSSP VSGNSNTPFN 600 KFPNSVSRNT HFESKSPHPN YSRTPHETYS KASSKNVPLS PPKQRVVNEH ALNIMSEKLQ 660 RTNLKEQTPE MDIENSSQNL PFSPMKISPI RASPVKTIPS SPSPTTNIFS APLNNITNCT 720 PMEDEWGEEG F 732 |
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| Keyword | KW-0131--Cell cycle |
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| Interpro | IPR007145--MAP65_Ase1_PRC1 |
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| PROSITE | |||||||||||||
| Pfam | PF03999--MAP65_ASE1 |
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| Gene Ontology | GO:0055028--C:cortical microtubule |