dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0035551 | ||||||||||||
| Uniprot Accession | Q9C103; EME1_SCHPO; | ||||||||||||
| Genbank Protein ID | NP_594132.2; | ||||||||||||
| Genbank Nucleotide ID | NM_001019556.2; | ||||||||||||
| Protein Name | Crossover junction endonuclease eme1 | ||||||||||||
| Protein Synonyms/Alias | Essential meiotic endonuclease 1; | ||||||||||||
| Gene Name | eme1 | ||||||||||||
| Gene Synonyms/Alias | mms4;slx2;SPAPB1E7.06c; | ||||||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||||||
| NCBI Taxa ID | 284812 | ||||||||||||
| Functional Description (View all) |
Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MTLQSTDSAI VIDSEADVDI SSSQASPSKD NIALSEHNVI TVLDTPQRST QCDSLLKSFS 60 TPLVSGSEDV LPSPRDALNI TNKKSVTDNL LLSLTSSNQS TNTNLNPSSR VEIINLNSSP 120 PNSLSSQPKH QEFHLFHTPT IPRTTQLSSK TSSPIVIPDD NEQVASPLSK KAASLTSSPL 180 KDFQSSPPLS TVLQKSHSLH DILLDTNDDD HFPFTQSPLT KTKSFNDALT SSSSILKPCM 240 PSIASPTSNR LSHAPSTPNL FPNQDSSNTI DLINNRSKTS VENQERTFNL TSDVHLDSPT 300 SPSKHSSIEP NTSQEDSFQE LPSLNKLSIQ SRAFKKMRLP KISRTTDTPP ASTSNSNKKN 360 LDKLKKMRKL CSRSLEPYEL DSNTQRKRKR YEDSLKKSKT LDKVDSLNRK MAKELDRKNS 420 KELQKINKVK RTKEECLSEI ILLSPDDWAS SWYSTVRSQL DSYNCQFVVN SNQPKDSIMW 480 KRKVNNVFNS STNRFELSIE HEQIEPFALL RLKCRDFIKY IEEDQADTFF HEMSEKFKGC 540 KLILLLEGIP NYFKSLKAEL NRQYAAAVNS GTRPLLFGSL SKYQNFTKEK LESEIVRFSF 600 EHSILINTSN DEKETAQWIV SFTGDIALSR YKHFSKFSAR ASTTEIGHVK SADRIENSLN 660 FMLRQILRVT PNIANAICDQ FDSIPSLIHH LKTHGEESLT NVVIQSSISE RNLGPVLSRR 720 IYNTFLCKEA SSDAP 736 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR006166--ERCC4_domain |
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| PROSITE | |||||||||||||
| Pfam | PF02732--ERCC4 |
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| Gene Ontology | GO:0048476--C:Holliday junction resolvase complex |