| Tag |
Content |
| dbPAF ID |
dbPAF-0034309 |
| Uniprot Accession |
Q99321; DDP1_YEAST; D6W2M1;
|
| Genbank Protein ID |
NP_014806.1;
|
| Genbank Nucleotide ID |
NM_001183582.1;
|
| Protein Name |
Diphosphoinositol polyphosphate phosphohydrolase DDP1 |
| Protein Synonyms/Alias |
Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase;Ap6A hydrolase;Diadenosine and diphosphoinositol polyphosphate phosphohydrolase 1;Diadenosine hexaphosphate hydrolase (AMP-forming); |
| Gene Name |
DDP1 |
| Gene Synonyms/Alias |
YOR163W;O3575; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate).Functional Description
May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate). |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MGKTADNHGP VRSETAREGR ENQVYSPVTG ARLVAGCICL TPDKKQVLMI TSSAHKKRWI 60
VPKGGVEKDE PNYETTAQRE TWEEAGCIGK IVANLGTVED MRPPKDWNKD IKQFENSRKD 120
SEVAKHPPRT EFHFYELEIE NLLDKFPECH KRHRKLYSYT EAKQNLIDAK RPELLEALNR 180
SAIIKDDK
189Fasta Sequence
>Q99321|DDP1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MGKTADNHGPVRSETAREGRENQVYSPVTGARLVAGCICLTPDKKQVLMITSSAHKKRWIVPKGGVEKDEPNYETTAQRETWEEAGCIGKIVANLGTVEDMRPPKDWNKDIKQFENSRKDSEVAKHPPRTEFHFYELEIENLLDKFPECHKRHRKLYSYTEAKQNLIDAKRPELLEALNRSAIIKDDK
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
|
| Interpro |
IPR000086--NUDIX_hydrolase_dom
IPR015797--NUDIX_hydrolase_dom-like
|
| PROSITE |
PS51462--NUDIX
|
| Pfam |
PF00293--NUDIX
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0034431--F:bis(5'-adenosyl)-hexaphosphatase activity
GO:0034432--F:bis(5'-adenosyl)-pentaphosphatase activity
GO:0008486--F:diphosphoinositol-polyphosphate diphosphatase activity
GO:0000298--F:endopolyphosphatase activity
GO:0052840--F:inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052846--F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052847--F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052843--F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052848--F:inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052844--F:inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052845--F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0050072--F:m7G(5')pppN diphosphatase activity
GO:0046872--F:metal ion binding
GO:1990174--F:phosphodiesterase decapping endonuclease activity
GO:0015961--P:diadenosine polyphosphate catabolic process
GO:0046855--P:inositol phosphate dephosphorylation
GO:0006798--P:polyphosphate catabolic process
GO:0090502--P:RNA phosphodiester bond hydrolysis, endonucleolytic
|
