dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0034308
Uniprot Accession Q99316; MPD2_YEAST; D6W1Y0;
Genbank Protein ID NP_014553.1;
Genbank Nucleotide ID NM_001183342.1;
Protein Name Protein disulfide isomerase MPD2
Protein Synonyms/Alias
Gene Name MPD2
Gene Synonyms/Alias YOL088C;O0941;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Non essential disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. Able to fold proteins by being directly oxidized by ERO1.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
28LAYSEAVTMVKSIEQcurated19823750
Sequence
(Fasta)		MKLHGFLFSV LSTCVVILPA LAYSEAVTMV KSIEQYFDIC NRNDSYTMIK YYTSWCQHCK 60
TLAPVYEELG ELYAKKANKD DTPINFLEVN CEFFGPTLCT DLPGFPIIEL VKPRTKPLVL 120
PKLDWSSMKF HERLWQRIKT WFNNPKYQLD TSRVVRFEGS RNLKSLSNFI DTVRSKDTEE 180
RFIEHIFDDS RNCNEELRSQ QLLCKAGKEY YSDTLSKLYG DVNGLEKERR RLEALIKQNG 240
DDLSKEVKEK LKIIRLQLSL LSHIEDQLED TSSHDEL 278
Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0413--Isomerase
KW-0676--Redox-active center
KW-1185--Reference proteome
KW-0732--Signal
Interpro

IPR012336--Thioredoxin-like_fold
IPR013766--Thioredoxin_domain
PROSITE

PS00014--ER_TARGET
PS51352--THIOREDOXIN_2
Pfam

PF00085--Thioredoxin
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0003756--F:protein disulfide isomerase activity
GO:0015035--F:protein disulfide oxidoreductase activity
GO:0045454--P:cell redox homeostasis
GO:0055114--P:oxidation-reduction process
GO:0006457--P:protein folding
GO:0034976--P:response to endoplasmic reticulum stress