dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0034306 | ||||||||
| Uniprot Accession | Q99314; SAS5_YEAST; D6W2R9; | ||||||||
| Genbank Protein ID | NP_014856.1; | ||||||||
| Genbank Nucleotide ID | NM_001183632.1; | ||||||||
| Protein Name | Something about silencing protein 5 | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | SAS5 | ||||||||
| Gene Synonyms/Alias | YOR213C; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing. In the complex, SAS5 is required for maximal histone acetyltransferase (HAT) activity of the complex, suggesting that it may be required to stabilize the complex or help in substrate recognition. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
|
||||||||
| Sequence (Fasta) | MDHSIEVTFR VKTQQVIIPE QNIRGNELPL RRWQMELLML DATGKEVEPT ILSKCIYHLH 60 SSFKQPKRRL NSLPFFIKET GWGEFNLKIE CFFIGNAGKF SIEHDLTFED DAYAVDYTVD 120 VPHEFSHLNS ELSKYFDLPW KVVSPEEEMS LRIADLPWIK SLALIDEDMM TDVVQMILND 180 PAVQRAIENH PRREQFFMFI TQLPDDLLMK IQAFLKLPNK NSTKQERTNF GSDAIHKDEP 240 VKAHNKLK 249 |
||||||||
| Keyword | KW-0156--Chromatin regulator |
||||||||
| Interpro | |||||||||
| PROSITE | PS51037--YEATS |
||||||||
| Pfam | PF03366--YEATS |
||||||||
| Gene Ontology | GO:0000790--C:nuclear chromatin |