dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0034299
Uniprot Accession Q99271; NAH1_YEAST; D6VYD3;
Genbank Protein ID NP_013239.1;
Genbank Nucleotide ID NM_001182025.1;
Protein Name Na(+)/H(+) antiporter
Protein Synonyms/Alias
Gene Name NHA1
Gene Synonyms/Alias YLR138W;L3149;L9606.4;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Sodium export from cell, takes up external protons in exchange for internal sodium ions.
Phosphorylation Sites
 dbPAF PTMs: 37 (View all)
PositionPeptidesSourceReferences ( PMIDs )
447GRHLNTITLTKTFTTdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 20702584; 19779198;
449HLNTITLTKTFTTHTPHOSIDA;curated21081558; 22817900; 19795423; 25315811
451NTITLTKTFTTHTTNcurated25315811
457KTFTTHTTNGDNGKScurated25315811
472SWMQRLPSLDKAGRSdbPTM 3.0;PhosphoGRID 2.0;curated15665377; 16381945; 23193290; 26040406; 22817900; 24961812;
479SLDKAGRSFSLHRMDPhosphoGRID 2.0;curated19779198; 22817900; 24961812
481DKAGRSFSLHRMDTQPhosphoGRID 2.0;curated20702584; 19779198; 22817900; 24961812; 19547744
487FSLHRMDTQMTLSGDcurated26040289; 24961812; 23825934
490HRMDTQMTLSGDEGEPhosphoGRID 2.0;curated19779198; 26040289; 22369663; 22817900; 24961812; 23825934;
492MDTQMTLSGDEGEAEdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 19779198; 26040289; 22369663;
566KGREIFSSRSKNEMYcurated19823750
568REIFSSRSKNEMYDDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 16381945; 23193290; 21177495; 19779198;
573SRSKNEMYDDDELNDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.017330950; 16381945; 23193290; 19060867; 19366988
623DEEEDEYTPEKEYSDcurated25315811
628EYTPEKEYSDNYNNTcurated25315811
629YTPEKEYSDNYNNTPcurated25315811
637DNYNNTPSFESSERScurated25315811
669ETESEIESEDEMENEPHOSIDA;curated21081558; 22817900; 19795423; 25315811
680MENESERSMASSEERcurated25315811
683ESERSMASSEERRIRPHOSIDA;curated21081558; 22817900; 19795423; 25315811
Sequence
(Fasta)		MAIWEQLEVS KAHVAYACVG VFSSIFSLVS LYVKEKLYIG ESTVAGIFGL IVGPVCLNWF 60
NPLKWGNSDS ITLEITRIVL CLQIFAVAVE LPRKYMLKHW VSVTMLLLPV MTAGWLIIGL 120
FVWILIPGLN FSASLLISAC ITATDPILAQ SVVSGKFAQR VPGHLRNLLS AESGCNDGMA 180
FPFLFLSMNL ILHPGNGREI VKDWICVTIL YECLFGCLLG CFIGYVGRIT IRFAEKKNII 240
DRESFLAFYV VLAFMCAGFG SILGVDDLLV SFAAGATFAW DGWFSQKTQE SNVSTVIDLL 300
LNYAYFIYFG AIIPWSQFNN GEIGTNVWRL IILSIVVIFL RRIPAVMILR PLIPDIKSWR 360
EALFVGHFGP IGVGAIFAAI LARGELESTF SDEPTPLNVV PSKEESKHWQ LIACIWPITC 420
FFIVTSIIVH GSSVAIITLG RHLNTITLTK TFTTHTTNGD NGKSSWMQRL PSLDKAGRSF 480
SLHRMDTQMT LSGDEGEAEE GGGRKGLAGG EDEEGLNNDQ IGSVATSGIP ARPAGGMPRR 540
RKLSRKEKRL NRRQKLRNKG REIFSSRSKN EMYDDDELND LGRERLQKEK EARAATFALS 600
TAVNTQRNEE IGMGGDEEED EYTPEKEYSD NYNNTPSFES SERSSSLRGR TYVPRNRYDG 660
EETESEIESE DEMENESERS MASSEERRIR KMKEEEMKPG TAYLDGNRMI IENKQGEILN 720
QVDIEDRNEA RDDEVSVDST AHSSLTTTMT NLSSSSGGRL KRILTPTSLG KIHSLVDKGK 780
DKNKNSKYHA FKIDNLLIIE NEDGDVIKRY KINPHKSDDD KSKNRPRNDS VVSRALTAVG 840
LKSKANSGVP PPVDEEKAIE GPSRKGPGML KKRTLTPAPP RGVQDSLDLE DEPSSEEDLG 900
DSYNMDDSED YDDNAYESET EFERQRRLNA LGEMTAPADQ DDEELPPLPV EAQTGNDGPG 960
TAEGKKKQKS AAVKSALSKT LGLNK 986
Keyword

KW-0050--Antiport
KW-0181--Complete proteome
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0915--Sodium
KW-0739--Sodium transport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR013928--Cation/H_antiporter_C
IPR006153--Cation/H_exchanger
IPR004712--Na+/H+_antiporter_fungi
IPR032516--Nha1
PROSITE
Pfam

PF00999--Na_H_Exchanger
PF08619--Nha1_C
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0015491--F:cation:cation antiporter activity
GO:0015079--F:potassium ion transmembrane transporter activity
GO:0015385--F:sodium:proton antiporter activity
GO:0030004--P:cellular monovalent inorganic cation homeostasis
GO:0030007--P:cellular potassium ion homeostasis
GO:0097623--P:potassium ion export across plasma membrane
GO:0006970--P:response to osmotic stress
GO:0036376--P:sodium ion export from cell