dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0034283
Uniprot Accession Q99186; AP2M_YEAST; D6W205;
Genbank Protein ID NP_014579.1;
Genbank Nucleotide ID NM_001183317.1;
Protein Name AP-2 complex subunit mu
Protein Synonyms/Alias Adaptin medium chain APM4;Clathrin assembly protein complex 2 mu medium chain;Clathrin coat assembly protein AP50;Clathrin coat-associated protein AP50;Mu2-adaptin;Plasma membrane adaptor AP-2 50 kDa protein;
Gene Name APM4
Gene Synonyms/Alias AMP1;YOL062C;O1210;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
27FKNSLKRSISDIFRVcurated22817900
149NMGGLLDSPDGNDVLcurated22817900
157PDGNDVLSSSSSPTSPhosphoGRID 2.0;curated19779198; 22817900
158DGNDVLSSSSSPTSSPhosphoGRID 2.0;curated19779198; 22817900
159GNDVLSSSSSPTSSAPhosphoGRID 2.0;curated19779198; 22817900
160NDVLSSSSSPTSSAGPhosphoGRID 2.019779198
161DVLSSSSSPTSSAGEPhosphoGRID 2.019779198
163LSSSSSPTSSAGELHPhosphoGRID 2.019779198
164SSSSSPTSSAGELHFPhosphoGRID 2.019779198
176LHFPKFLTKRSSSFLcurated20377248
179PKFLTKRSSSFLGQGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 17330950; 20702584; 19823750;
180KFLTKRSSSFLGQGDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 17330950; 20702584; 19823750;
181FLTKRSSSFLGQGDSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 17330950; 20702584; 19779198;
188SFLGQGDSTSDFYDNPhosphoGRID 2.0;curated19779198; 22817900; 24961812; 23825934; 25315811
189FLGQGDSTSDFYDNNcurated19823750; 24961812; 20377248
190LGQGDSTSDFYDNNKcurated24961812; 20377248
277LAQQQRHSGSDFGNKdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17287358; 17563356; 16381945; 23193290; 19060867; 19366988;
279QQQRHSGSDFGNKNFPhosphoPep 2.0;curated19060867; 19823750; 25315811
466VVRYFTISGKDSKHRcurated22817900
470FTISGKDSKHRAVKWcurated22817900
Sequence
(Fasta)		MISGVLVYSS RGELVLNKFF KNSLKRSISD IFRVQVINNL DVRSPVLTLG STTFHHIRSR 60
HGDNLWLVTI TRSNANSAAI WEFLYKLDAV MNAYRLDREE ALKEEFMIVH EMLDIMLGGN 120
GIPIDTELNS VIAQMSVKPV RNMGGLLDSP DGNDVLSSSS SPTSSAGELH FPKFLTKRSS 180
SFLGQGDSTS DFYDNNKITW RPKGIIHKKD EVFLYVNERI NILVSRDGSI LKSYVDGTID 240
ITTHLSGTPI CRFGLNDSLG MQSEDEKKWL AQQQRHSGSD FGNKNFIPKA AAGSVLLEDC 300
KFHECVSLDK FNRNHIIEFV PPDGSMELMK YHVRDNINLP FKVTPIVTHS TRDNEIDYRI 360
TLKSLFPGKL SAKDVVLHIP VPPSTVDCKI SVSNGHCKFV PEENAMIWRF NKYNGLTENT 420
LSAVTVSTSD TTQLNLQQWT RPPISLEFEV MMFSNSGLVV RYFTISGKDS KHRAVKWIKY 480
ISKAGSYEVR Y 492
Keyword

KW-0168--Coated pit
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR001392--Clathrin_mu
IPR011012--Longin-like_dom
IPR028565--MHD
PROSITE

PS51072--MHD
Pfam

PF00928--Adap_comp_sub
Gene Ontology

GO:0030122--C:AP-2 adaptor complex
GO:0006897--P:endocytosis
GO:0006886--P:intracellular protein transport