dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0034272
Uniprot Accession Q96WV5; COPA_SCHPO;
Genbank Protein ID NP_595279.1;
Genbank Nucleotide ID NM_001021186.2;
Protein Name Putative coatomer subunit alpha
Protein Synonyms/Alias Alpha-coat protein;Alpha-COP;
Gene Name SPBPJ4664.04
Gene Synonyms/Alias
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
409NVSSRSNSLPLKDNIdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
913IFLWKRNSPLAADHIcurated22817900
942QVGAINFSPLKTRFLdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
Sequence
(Fasta)
MEMLTKFESR SSRAKGVAFH PTQPWILTSL HNGRIQLWDY RMGTLLDRFD GHDGPVRGIA 60
FHPTQPLFVS GGDDYKVNVW NYKSRKLLFS LCGHMDYVRV CTFHHEYPWI LSCSDDQTIR 120
IWNWQSRNCI AILTGHSHYV MCAAFHPSED LIVSASLDQT VRVWDISGLR MKNAAPVSMS 180
LEDQLAQAHN SISNDLFGST DAIVKFVLEG HDRGVNWCAF HPTLPLILSA GDDRLVKLWR 240
MTASKAWEVD TCRGHFNNVS CCLFHPHQEL ILSASEDKTI RVWDLNRRTA VQTFRRDNDR 300
FWFITVHPKL NLFAAAHDSG VMVFKLERER PAHALNINTL LYVNKEKSIV SYDLLRAQST 360
TVASVKHLGS AWLPPRSLSY NPAEKVALLT SSADNGVYEL VNVSSRSNSL PLKDNIKGPG 420
DDAIFVARNR FAVFSRSDQT IEIKDLSNKV TKTIQLPEKT RDIFFAGMGH VLLSTATQVH 480
LFDLQQKKIV SSFNANRVKY VVWSNDNSQA ALLGKHYVYI VKKNLELITS IHETIRIKSA 540
VWVENNVLLY ATLDHLKYAL MSGDTGVIKT LESTLYLVKA KGNMVFALNR AAEPVSFEID 600
PTEYLFKLAL LRKDYEQVLH LIQNSNLVGQ AIIAYLQKKG YPEIALQFVE DPSTRFELAL 660
ECGNLETALE LARTIDRPEV WSRLASDAMS YGNHKIAEIT FQKLRYFEKL SFLYLITGNA 720
EKLQKMAIIA EKRNDTLSLF QNSLYLNEVE SRINILEQAG MYPIAYLTAK SNGLEEKAQQ 780
ILSHCNKTEE EIKLPSLGSA FTTPVPVNET YTHNWPLLDT SHSTFEKSLQ ERMEQLAIER 840
QEEQESEEEY EEVEQSLMDV VDEMSDLAES VPEEEVDGWE VEDLAPEEAV NDVVDDASAF 900
VGADEIFLWK RNSPLAADHI AAGDFESAMK ILNKQVGAIN FSPLKTRFLE IYTASRVYLP 960
TISGLDPLVS YVRRNAETAE RSQALPFITR NLASIKSHEL HEAYRLVKAN KILEAQICFR 1020
SIIYLALTTV ANSEEEADEI SALIDECCRY IVALSCELER RRLGEEDTKR ALELSYYFAS 1080
ADLQPMHSII ALRLAINASH KLKNYKSASF LGNKLLQLAE SGPAAEAANR AITLGDRNPH 1140
DAFEIEYDPH VEMRICPKTL TPVYSGDDFD VCSVCGAVYH KGYVNEVCTV CDVGGIGQKG 1200
TGRRFFA 1208
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER