dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0032530
Uniprot Accession Q92331; VPS5_YEAST; D6W2D1; E9P8U6; Q08483;
Genbank Protein ID NP_014712.2;
Genbank Nucleotide ID NM_001183488.1;
Protein Name Vacuolar protein sorting-associated protein 5
Protein Synonyms/Alias Carboxypeptidase Y-deficient protein 10;Vacuolar protein-targeting protein 5;
Gene Name VPS5
Gene Synonyms/Alias GRD2;PEP10;VPT5;YOR069W;YOR29-20;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Plays a role in vesicular protein sorting. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
27DKTQSLVSNSIESIGPHOSIDA;curated21081558; 22369663; 22817900; 19795423; 24961812
29TQSLVSNSIESIGQIPHOSIDA;curated21081558; 22369663; 22817900; 19795423; 24961812; 25315811
32LVSNSIESIGQISTNPHOSIDA;curated21081558; 25704821; 22369663; 22817900; 24961812; 25315811
37IESIGQISTNEERKDdbPTM 3.0;PHOSIDA;SysPTM 2.0;curated18407956; 16381945; 23193290; 21081558; 19366988; 25704821;
38ESIGQISTNEERKDNPHOSIDA;curated21081558; 22817900; 19795423; 25315811
53ELLETTASFADKIDLcurated22369663; 22817900; 24961812; 25315811; 19547744
62ADKIDLDSAPEWKDPcurated22369663; 25315811
72EWKDPGLSVAGNPQLcurated25315811
85QLEEHDNSKADDLINcurated25315811
93KADDLINSLAPEQDPcurated24961812
107PIADLKNSTTQFIATcurated22369663; 25315811
142TIYDANTSPNTSKSIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
182SLKAKRTTASDDTIKcurated19823750
184KAKRTTASDDTIKTPdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 26040289; 22817900; 24961812;
187RTTASDDTIKTPFTDcurated26040289; 24961812
251PQTGANISSPAEVEEPhosphoPep 2.0;curated19060867; 22369663
252QTGANISSPAEVEENdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 26040289; 22369663; 22817900
Sequence
(Fasta)		MDYEDNLEAP VWDELNHEGD KTQSLVSNSI ESIGQISTNE ERKDNELLET TASFADKIDL 60
DSAPEWKDPG LSVAGNPQLE EHDNSKADDL INSLAPEQDP IADLKNSTTQ FIATRESGGA 120
LFTGNANSPL VFDDTIYDAN TSPNTSKSIS GRRSGKPRIL FDSARAQRNS KRNHSLKAKR 180
TTASDDTIKT PFTDPLKKAE KENEFVEEPL DDRNERRENN EGKFTASVEK NILEQVDRPL 240
YNLPQTGANI SSPAEVEENS EKFGKTKIGS KVPPTEKAVA FKVEVKDPVK VGELTSIHVE 300
YTVISESSLL ELKYAQVSRR YRDFRWLYRQ LQNNHWGKVI PPPPEKQSVG SFKENFIENR 360
RFQMESMLKK ICQDPVLQKD KDFLLFLTSD DFSSESKKRA FLTGSGAIND SNDLSEVRIS 420
EIQLLGAEDA AEVLKNGGID AESHKGFMSI SFSSLPKYNE ADEFFIEKKQ KIDELEDNLK 480
KLSKSLEMVD TSRNTLAAST EEFSSMVETL ASLNVSEPNS ELLNNFADVH KSIKSSLERS 540
SLQETLTMGV MLDDYIRSLA SVKAIFNQRS KLGYFLVVIE NDMNKKHSQL GKLGQNIHSE 600
KFREMRKEFQ TLERRYNLTK KQWQAVGDKI KDEFQGFSTD KIREFRNGME ISLEAAIESQ 660
KECIELWETF YQTNL 676
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR001683--Phox
IPR015404--Vps5_C
PROSITE

PS50195--PX
Pfam

PF00787--PX
PF09325--Vps5
Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0019898--C:extrinsic component of membrane
GO:0000139--C:Golgi membrane
GO:0030904--C:retromer complex
GO:0030905--C:retromer, tubulation complex
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0006897--P:endocytosis
GO:0045053--P:protein retention in Golgi apparatus
GO:0015031--P:protein transport
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0016050--P:vesicle organization