dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0032529 | ||||||||||||
| Uniprot Accession | Q92328; MDM12_YEAST; D6W258; Q08064; | ||||||||||||
| Genbank Protein ID | NP_014634.1; | ||||||||||||
| Genbank Nucleotide ID | NM_001183263.1; | ||||||||||||
| Protein Name | Mitochondrial distribution and morphology protein 12 | ||||||||||||
| Protein Synonyms/Alias | Mitochondrial inheritance component MDM12; | ||||||||||||
| Gene Name | MDM12 | ||||||||||||
| Gene Synonyms/Alias | YOL009C; | ||||||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||||||
| NCBI Taxa ID | 559292 | ||||||||||||
| Functional Description (View all) |
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MSFDINWSTL ESDNRLNDLI RKHLNSYLQN TQLPSYVSNL RVLDFDLGKV GPAITLKEIT 60 DPLDEFYDSI REEADQETEE NNDNKEDSEH ICPDRTIANH EGPKDDFEAP VVMPSPNDIQ 120 FLLEVEYKGD LLVTIGADLV LNYPVEKFMT LPVKLSISDI GLHSLCIVAC LSKQLFLSFL 180 CDVSDPALDD NQTVLDPKGP ILAATKPLER ISIVRSMKIE TEIGEQYQGQ GSVLRSVGEL 240 EQFLFTIFKD FLRKELAWPS WINLDFNDGD E 272 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR027532--Mdm12 |
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| PROSITE | |||||||||||||
| Pfam | |||||||||||||
| Gene Ontology | GO:0005789--C:endoplasmic reticulum membrane |