dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0032023
Uniprot Accession Q8WZK0; US107_SCHPO; Q9UTX7;
Genbank Protein ID NP_595250.1;
Genbank Nucleotide ID NM_001021156.2;
Protein Name U1 snRNP-associated protein usp107
Protein Synonyms/Alias
Gene Name usp107
Gene Synonyms/Alias snu71;SPBC839.10;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
444EERVNNTSFGTYLSEcurated22817900
Sequence
(Fasta)
MQRQNTQAAG MPMMPQVPMV GNGVPYVVPI QPVFAPLPPD YRSLYKKLYG QGAFLVDNPV 60
EASSPYDFSQ PILKFGKLPI KQVLRDNESQ QKDRKNLPRN QKSNEIQEKQ TFQTPSSEKS 120
TTERESRPFV PPNSQQMRRM LFIGNIPKEL DDFWMDKILR LSGKLASWRR VADADNSMTS 180
FGFAEFESNE QFSRALEALN DFVVPPLYEG GPSTRLSLIT DVENEGLYRE WQTSRYARNK 240
QKEINILQQI RFNLERICQD IGNFDVRSRI ERAARQAREK NEKLLQNVKT SEIPINAADL 300
EGINPELLPV IEEEIRSFRD QSAMKKREKQ RSKDEYASLY KEYTRKEQEK LRKQNDDLQN 360
LLSKHRISRI PMSTVNAFLR AEDSIPESFS DEQAYYEEKR RKDQLEAEEY YARERRWMNR 420
EKARTAALER EAAREEEERV NNTSFGTYLS EKLASFDDDE EARVSRDEYF VDRAAWIRHR 480
AVARAREEDA DALDRKEEER ELRTRGEGAT VETENYVENG KLVTSEMPQH ENGPFKIKIQ 540
TKKPAVPSER REFGLPERLL LEEEDEEPQG YSPNPQKPKP AMEENDAEKT KRLRSLIEKI 600
PVEAESLWAL PIDWSKVTED LLKEEMQAFV TKKIIEYIGI QEDSLITFTI DHIRQHKGAE 660
QLVSELDLAL AEDAPEFVSK VYRYLHVLLI LRSEA 696
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0747--Spliceosome

Interpro

IPR012677--Nucleotide-bd_a/b_plait
IPR002483--PWI_dom
IPR000504--RRM_dom

PROSITE

PS51025--PWI
PS50102--RRM

Pfam

PF01480--PWI
PF00076--RRM_1

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0005685--C:U1 snRNP
GO:0071004--C:U2-type prespliceosome
GO:0003729--F:mRNA binding
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0000395--P:mRNA 5'-splice site recognition
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0000381--P:regulation of alternative mRNA splicing, via spliceosome