| Tag |
Content |
| dbPAF ID |
dbPAF-0028940 |
| Uniprot Accession |
Q8IXH6; T53I2_HUMAN; A8K8S8; E1P5P6; Q5JX64; Q8IYL5; Q9NU00;
|
| Genbank Protein ID |
NP_067025.1; XP_005260533.1; XP_011527254.1; XP_011527255.1;
|
| Genbank Nucleotide ID |
NM_021202.1; XM_005260476.2; XM_011528952.1; XM_011528953.1;
|
| Protein Name |
Tumor protein p53-inducible nuclear protein 2 |
| Protein Synonyms/Alias |
Diabetes and obesity-regulated gene;p53-inducible protein U;PIG-U; |
| Gene Name |
TP53INP2 |
| Gene Synonyms/Alias |
C20orf110;DOR;PINH; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.Functional Description
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MFQRLSSLFF STPSPPEDPD CPRAFVSEED EVDGWLIIDL PDSYAAPPSP GAAPAPAGRP 60
PPAPSLMDES WFVTPPACFT AEGPGLGPAR LQSSPLEDLL IEHPSMSVYV TGSTIVLEPG 120
SPSPLPDAAL PDGDLSEGEL TPARREPRAA RHAAPLPARA ALLEKAGQVR RLQRARQRAE 180
RHALSAKAVQ RQNRARESRP RRSKNQSSFI YQPCQRQFNY
221Fasta Sequence
>Q8IXH6|TP53INP2|Homo sapiens(Human)
MFQRLSSLFFSTPSPPEDPDCPRAFVSEEDEVDGWLIIDLPDSYAAPPSPGAAPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSSPLEDLLIEHPSMSVYVTGSTIVLEPGSPSPLPDAALPDGDLSEGELTPARREPRAARHAAPLPARAALLEKAGQVRRLQRARQRAERHALSAKAVQRQNRARESRPRRSKNQSSFIYQPCQRQFNY
|
| Keyword |
KW-0010--Activator
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR029431--TP53INP
IPR029558--TP53INP2
|
| PROSITE |
|
| Pfam |
PF14839--DOR
|
| Gene Ontology |
GO:0005776--C:autophagosome
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0000045--P:autophagosome assembly
GO:1903828--P:negative regulation of cellular protein localization
GO:0001649--P:osteoblast differentiation
GO:0010508--P:positive regulation of autophagy
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0001894--P:tissue homeostasis
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
|
