| Tag |
Content |
| dbPAF ID |
dbPAF-0020050 |
| Uniprot Accession |
Q4LB35; FOL1_SCHPO;
|
| Genbank Protein ID |
NP_595420.2;
|
| Genbank Nucleotide ID |
NM_001021327.2;
|
| Protein Name |
Folic acid synthesis protein fol1 |
| Protein Synonyms/Alias |
|
| Gene Name |
fol1 |
| Gene Synonyms/Alias |
SPBC1734.03;SPBC337.19; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.Functional Description
Catalyzes three sequential steps of tetrahydrofolate biosynthesis. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MKSLVNLWGI YPFIRNNSLH GFAKIPRIVS TIPRQLRFSS LRHPTRQMDL IHDTVVVENL 60
NTFAVVGQDQ WKRKEPQPVQ IDVYMRNNVQ LAGEKDELKS TIHYGIASKL LRKEIEGSFF 120
TTPKDLVNKI ASLCFEDVID TSHVSIKLTL PKCVLRSKNG LHYYAERERN STSNFVDRIE 180
FSDLELATIL GIHAFERQEK QRVCLNISFA NTEVEALEIA RAIAEYVEQS AFLTIEALVV 240
NLSKYLCFTK NLDDISIKAE KPSAITFANA SAVQIYRTRS YFLQESLHKY ESTKNKIAYL 300
SFGSNIGDKF EQIQTALSML HKIEGIRVLD VSPLYETEPM YYKDQPSFLN GVCKIETRMS 360
PINLLRACQS IEQEMGRIKT ILKGPRCIDL DIVLYEDCVY ESEVLTIPHL GLQEREFVLR 420
PLLALSPDLV HPYTHQPLQE ALDKLPSQGI RLYSSFDNKK IINGALTMGI LNVTPDSFSD 480
GGKVSQNNIL EKAKSMVGDG ASILDIGGQS TKPGADPVSV EEELRRVIPM ISLLRSSGIT 540
VPISIDTYYS KVAKLAIEAG ANIINDVTGG MGDEKMLPLA ASLQVPICIM HMRGTPETMK 600
ALSIYEKDIV EEVAVELSSR VEAAVQSGVH RYNIILDPGF GFAKTPKQSA GLLGRLHELM 660
KKPQFKDMHW LSGPSRKGFT GYFTGDASPK DRIWGTSACV TASVLQGVSI VRVHDTKEMS 720
KVVGMANAIR YVP
734Fasta Sequence
>Q4LB35|fol1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MKSLVNLWGIYPFIRNNSLHGFAKIPRIVSTIPRQLRFSSLRHPTRQMDLIHDTVVVENLNTFAVVGQDQWKRKEPQPVQIDVYMRNNVQLAGEKDELKSTIHYGIASKLLRKEIEGSFFTTPKDLVNKIASLCFEDVIDTSHVSIKLTLPKCVLRSKNGLHYYAERERNSTSNFVDRIEFSDLELATILGIHAFERQEKQRVCLNISFANTEVEALEIARAIAEYVEQSAFLTIEALVVNLSKYLCFTKNLDDISIKAEKPSAITFANASAVQIYRTRSYFLQESLHKYESTKNKIAYLSFGSNIGDKFEQIQTALSMLHKIEGIRVLDVSPLYETEPMYYKDQPSFLNGVCKIETRMSPINLLRACQSIEQEMGRIKTILKGPRCIDLDIVLYEDCVYESEVLTIPHLGLQEREFVLRPLLALSPDLVHPYTHQPLQEALDKLPSQGIRLYSSFDNKKIINGALTMGILNVTPDSFSDGGKVSQNNILEKAKSMVGDGASILDIGGQSTKPGADPVSVEEELRRVIPMISLLRSSGITVPISIDTYYSKVAKLAIEAGANIINDVTGGMGDEKMLPLAASLQVPICIMHMRGTPETMKALSIYEKDIVEEVAVELSSRVEAAVQSGVHRYNIILDPGFGFAKTPKQSAGLLGRLHELMKKPQFKDMHWLSGPSRKGFTGYFTGDASPKDRIWGTSACVTASVLQGVSIVRVHDTKEMSKVVGMANAIRYVP
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0289--Folate biosynthesis
KW-0418--Kinase
KW-0456--Lyase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR006390--DHP_synth
IPR011005--Dihydropteroate_synth-like
IPR006157--FolB_dom
IPR016261--Folic_acid_synth
IPR000550--Hppk
IPR000489--Pterin-binding_dom
|
| PROSITE |
PS00793--DHPS_2
PS50972--PTERIN_BINDING
|
| Pfam |
PF02152--FolB
PF01288--HPPK
PF00809--Pterin_bind
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0003848--F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0005524--F:ATP binding
GO:0004150--F:dihydroneopterin aldolase activity
GO:0004156--F:dihydropteroate synthase activity
GO:0016301--F:kinase activity
GO:0046872--F:metal ion binding
GO:0046656--P:folic acid biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process
|
