dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0018958
Uniprot Accession Q3E7C1; TFB5_YEAST; D6VS66;
Genbank Protein ID NP_076886.3;
Genbank Nucleotide ID NM_001184469.3;
Protein Name RNA polymerase II transcription factor B subunit 5
Protein Synonyms/Alias General transcription and DNA repair factor IIH subunit TFB5;TFIIH subunit TFB5;
Gene Name TFB5
Gene Synonyms/Alias YDR079C-A;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
15ALVQCDPSIKALILQPhosphoGRID 2.0;curated19823750; 19795423; 22817900
Sequence
(Fasta)		MARARKGALV QCDPSIKALI LQIDAKMSDI VLEELDDTHL LVNPSKVEFV KHELNRLLSK 60
NIYNPMDEEE NQ 73
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR009400--TFIIH_TTDA/Tfb5
PROSITE
Pfam

PF06331--Tfb5
Gene Ontology

GO:0000439--C:core TFIIH complex
GO:0005829--C:cytosol
GO:0005675--C:holo TFIIH complex
GO:0005634--C:nucleus
GO:0006289--P:nucleotide-excision repair
GO:0070816--P:phosphorylation of RNA polymerase II C-terminal domain
GO:0006366--P:transcription from RNA polymerase II promoter