dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0018161
Uniprot Accession Q1MTQ1; TEA2_SCHPO; O94732;
Genbank Protein ID NP_596620.1;
Genbank Nucleotide ID NM_001022541.2;
Protein Name Kinesin-like protein tea2
Protein Synonyms/Alias Kinesin-like protein 4;Tip elongation aberrant protein 2;
Gene Name tea2
Gene Synonyms/Alias klp4;SPBC1604.20c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
82GVTEKLMSPGTLDRYdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)
MSSSSSKPVN TGLVTPRRYS TMTGIRTGPS QSGTGSIPYS PTSPLSRNFS NYSIPMLRSN 60
STQTNVNGPT AFDLGVTEKL MSPGTLDRYT RPALYPSKDL DYLKNEYVNY ESTTSQQTNS 120
KGLKESNFVG SGIITSIRIR PIGKNQGVWS HGKLSNDPYG REYIRQQTST SSSTIQQEYL 180
FNNVFGMESK NYDIYKRSVK SVVRNVFSGY NGIVFAYGMT GTGKTYSMQG TENEPGIIPL 240
AMNDLFEMVE NNSDDDTFQI RISYLEIYNE RIRDLIGNSD EEPRIRENAS GEVNVTPLTR 300
VLVTSPEEVS QVIEQCNAIR KTAATDFNTY SSRSHAILQV FLIRNNPTAH TSQISSLSLV 360
DLAGSERASA HHERRKEGAF INKSLLTLGT VISRLSAAAN PSLTSNSGHI PYRESKLTRL 420
LQQSLSGQSQ ISLLATISIE SNHTMETTNT LKFASRAQNL PQDIRQAEAV TNVQAELASL 480
HSALEKNAQE VEYYASLVKQ LTSDLEERDT YIAMLEAERS QGTAISRARL RMEELLSDHN 540
FEIADLRDEL QDKEQIIYAL RYAQKQRDIA DFNQSLAKFP HKILKKNVTR GSRSSSDQFS 600
NETKTEILPD DQQQSKKDSV TQETQLLS 629
Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR027640--Kinesin-like_fam
IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase

PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2

Pfam

PF00225--Kinesin

Gene Ontology

GO:0051285--C:cell cortex of cell tip
GO:0005737--C:cytoplasm
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0005524--F:ATP binding
GO:0008574--F:ATP-dependent microtubule motor activity, plus-end-directed
GO:0016887--F:ATPase activity
GO:0008017--F:microtubule binding
GO:0034613--P:cellular protein localization
GO:0071963--P:establishment or maintenance of cell polarity regulating cell shape
GO:0007018--P:microtubule-based movement
GO:0010570--P:regulation of filamentous growth