| Tag |
Content |
| dbPAF ID |
dbPAF-0018160 |
| Uniprot Accession |
Q1MTQ0; BRL1_SCHPO;
|
| Genbank Protein ID |
NP_588497.1;
|
| Genbank Nucleotide ID |
NM_001023487.2;
|
| Protein Name |
E3 ubiquitin-protein ligase brl1 |
| Protein Synonyms/Alias |
BRE1-like protein 1;RING finger protein 2; |
| Gene Name |
brl1 |
| Gene Synonyms/Alias |
rfp2;SPCC1919.15;SPCC790.01; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.Functional Description
E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 210 | LTSASERSIENIADD | curated | 22817900 |
|
Sequence
(Fasta) | MSVVNESRKR RRLIHSEKET RRLDLGEEDD LELFQKEAAW RRSREYEHLT VLEKKLYEYW 60
ESLVLKLDHY VAAALENHEQ SFEELEKITA SLYQPDDNLQ TLDLSLAEFS LIKDAQNYLN 120
KYASYFQAHE PTLQKLAKFG SFKLKETPNV HEWIDQRQVH FTSMINYRTS QLKLALLKRK 180
LSFFREALNS AELEWKRVQQ DQLTSASERS IENIADDIPA SEPKAILENG EGCLNDNDNI 240
SKLKNNFQSQ ADLMQANINS KLDELSQKST RAAQLYVDIM GITDERVSRE PHYLELKGVL 300
SSNEEKIESI NRDLSSLFED IQFFISQRTK RQKDIIDLKL ACVKEKQQLI KTLESSLTQI 360
RNERDSLVAK QQMQYTNNLF FDDMMLLLSN LSNARVAILE GYSNRLCIWD RIERSKTGEM 420
NNVLDEKEEI SASSALEKLI KNNSCLEAEL PSMYAAFDQS QSRLLKKYEE LETKEKKALE 480
MHYEKARATQ KYFAAMKARD ILMTEKKTLK LAENKEHDYI GKLQEREHAL TKYESSLKAE 540
LEVYKQIKEI YGKHSVEVLT EDKHLQVKQT KLTQKLEDLI ESVQKSGEKL MIMHQKLFHL 600
QEEHTILSIK ASYNKKESHL INQAYETQEA QVYKGMLKCS VCNFSNWKSK LIPNCGHAFC 660
SNCMEPFYEH KTSTCPQCET PFSVSDILTI HL
693Fasta Sequence
>Q1MTQ0|brl1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MSVVNESRKRRRLIHSEKETRRLDLGEEDDLELFQKEAAWRRSREYEHLTVLEKKLYEYWESLVLKLDHYVAAALENHEQSFEELEKITASLYQPDDNLQTLDLSLAEFSLIKDAQNYLNKYASYFQAHEPTLQKLAKFGSFKLKETPNVHEWIDQRQVHFTSMINYRTSQLKLALLKRKLSFFREALNSAELEWKRVQQDQLTSASERSIENIADDIPASEPKAILENGEGCLNDNDNISKLKNNFQSQADLMQANINSKLDELSQKSTRAAQLYVDIMGITDERVSREPHYLELKGVLSSNEEKIESINRDLSSLFEDIQFFISQRTKRQKDIIDLKLACVKEKQQLIKTLESSLTQIRNERDSLVAKQQMQYTNNLFFDDMMLLLSNLSNARVAILEGYSNRLCIWDRIERSKTGEMNNVLDEKEEISASSALEKLIKNNSCLEAELPSMYAAFDQSQSRLLKKYEELETKEKKALEMHYEKARATQKYFAAMKARDILMTEKKTLKLAENKEHDYIGKLQEREHALTKYESSLKAELEVYKQIKEIYGKHSVEVLTEDKHLQVKQTKLTQKLEDLIESVQKSGEKLMIMHQKLFHLQEEHTILSIKASYNKKESHLINQAYETQEAQVYKGMLKCSVCNFSNWKSKLIPNCGHAFCSNCMEPFYEHKTSTCPQCETPFSVSDILTIHL
|
| Keyword |
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR013956--E3_ubiquit_lig_BRE1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
|
| PROSITE |
PS00518--ZF_RING_1
PS50089--ZF_RING_2
|
| Pfam |
PF08647--BRE1
PF00097--zf-C3HC4
|
| Gene Ontology |
GO:0033503--C:HULC complex
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0008270--F:zinc ion binding
GO:0031497--P:chromatin assembly
GO:0006342--P:chromatin silencing
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0071894--P:histone H2B conserved C-terminal lysine ubiquitination
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
|
