dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016740
Uniprot Accession Q12754; RRP12_YEAST; D6W400; Q7LH12;
Genbank Protein ID NP_015313.1;
Genbank Nucleotide ID NM_001183826.1;
Protein Name Ribosomal RNA-processing protein 12
Protein Synonyms/Alias
Gene Name RRP12
Gene Synonyms/Alias YPL012W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 In association with GSP1, required for nuclear export of both pre-40S and pre-60S ribosomal subunits. Required for the late maturation of the 18S and 5.8S rRNA of the pre-40S ribosomes and for maturation of the 25S and 5.8S rRNA of the pre-60S ribosomes.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
455SNPHFLKSLKIVDTWPHOSIDA;curated21081558; 22817900; 19795423
461KSLKIVDTWRVNEEQPHOSIDA;curated21081558; 22817900; 19795423
841TKDVNEKSRETAFDTcurated19823750
1038EEVTTGVSDVAATKGcurated24961812
1050TKGSRFMSAFDEAVYPhosphoGRID 2.021126336
1057SAFDEAVYGSDEENDPhosphoPep 2.0;curated19060867; 19795423
1059FDEAVYGSDEENDNGdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 21126336; 19684113; 19779198;
1067DEENDNGSDQEENVAdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19684113; 19779198;
1131DDAFNFDSEGKLVVKcurated24961812; 25315811
1186FRKNGKDSDEFGDDDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;curated17563356; 16381945; 23193290; 19823750; 19795423; 21081558;
Sequence
(Fasta)		MDQDKVAFLL ELEDKLAKIR SQVNSKLENQ KHIAIILTAV EENIAGQATN DVSKNIVNYI 60
ISFMSLLDQA VDPSTHEIKD IQLASSSTYL LDLIFHYSPK VLLRSKFSEI LTKIAPCITA 120
EKANAPLIRA AIGCLESLLI AQDAQAWNNT YDLNVTPKRG LQGILELSLD VRPKVRKRAL 180
DAVHAVLLNP PVAPTAEHVA AVFVADFCDK QLAGILNDLS NLSNKQLKAQ KTKEDINASV 240
MRSLRLITSV VSTGQWPSSQ IEPLCDVLLG VTKSSEQYLV SASFECFESM FKTMAETTIS 300
SGLAENKYLR VLDTIFALKP SNVDTLLTKS WIAVVIKGMS TYATHQPLKA LRKIPGVFHI 360
MCTYLASETP EVYQAASQCL ISILSESVKD DLLLYTPSVD EKVFKNVDEI ISQIAKTFID 420
FLSIRYSHCS REILKILVAA FNKFRYRSNP HFLKSLKIVD TWRVNEEQFM DLRNEIELVI 480
GASISAMGPE MILAEAPLNL DNPSSERPGR AWLLPLIRDY TKNANLATFQ NELAPYIKSF 540
QSKFDKVPEE SIQLRVFQTI VDQIWSTLPR FCELPMDLRE SFTDEFASEL SSLLYSEVEL 600
RTTICHALKV LAESNVSYAE ESSSHNVLLL QRFPISEAQK NIEYLSTKST NLLAVLFNVY 660
TQTTPNARSY ILETIDQYLK ITSKEDLEKT FNNVCGLLKN SMNEESSGNV NKEKKKPQLT 720
ATLLDLIICM ITYLPVSSYS ALFSMFSLTV NSADALIQKR AYRIITKLSE LKSGSTAVAQ 780
FISDIENVMV DSASSVQTSA KAARLTAIKT IVELLPLDHL DFIVRTVAEV ILSTKDVNEK 840
SRETAFDTLI CMGRKMNEPN GIIKLFQIPG YDPTTPDQSS SISEFFKIIS AGLIGESQHM 900
VSSSITGYAC LVFEFKNELD SGILMDIYDT IELYLTSNSR EIVKSAIGFT KVCVLGLPEE 960
LMRPKVPELL LKLLRWSHEH TGHFKAKVKH IIERLIRRFG YDYIEANFPE EDRRLLTNIR 1020
KMRNRNKRKD EEVTTGVSDV AATKGSRFMS AFDEAVYGSD EENDNGSDQE ENVAGGKMKN 1080
GAKQFIVESG DNPLDLLDSQ TLAHISSTRP KKFNKNQNRA RFNDDAFNFD SEGKLVVKGQ 1140
PKPSTNVDDP LSAVTSGINA YLEAVKSGPV RGQRNKLKFR KNGKDSDEFG DDDDGEKDSR 1200
LMRGRVNQGN KIGKHNKKGP KFKSRKKL 1229
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0690--Ribosome biogenesis
KW-0694--RNA-binding
Interpro

IPR016024--ARM-type_fold
IPR012978--Uncharacterised_NUC173
PROSITE
Pfam

PF08161--NUC173
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0030688--C:preribosome, small subunit precursor
GO:0005840--C:ribosome
GO:0003723--F:RNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0042254--P:ribosome biogenesis