dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0016736
Uniprot Accession Q12743; DFM1_YEAST; D6VT43; Q7LIJ5;
Genbank Protein ID NP_010699.1;
Genbank Nucleotide ID NM_001180719.1;
Protein Name DER1-like family member protein 1
Protein Synonyms/Alias
Gene Name DFM1
Gene Synonyms/Alias YDR411C;D9461.2;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
312DSGRASGSQLRSGPScurated25315811
319SQLRSGPSNLNQFQGcurated25315811
336QRVGQTNSPSDSQ--curated25315811
338VGQTNSPSDSQ----curated25315811
340QTNSPSDSQ------curated25315811
Sequence
(Fasta)
MAGPRNVRTL HGNGGRNNDV MGPKEFWLNI PPITRTLFTL AIVMTIVGRL NLINPWYFIY 60
VWNLTFKKVQ IWRLLTSCVM LSSRAMPALM ELYSIYDRSS QLERGHFGPG LSNRRGPMVT 120
VDYAYYLCFC ILAITTATTI IYGSYYPVVL TSGFISCITY TWSIDNANVQ IMFYGLIPVW 180
GKYFPLIQLF ISFVFNEGDF VISLIGFTTG YLYTCLDTHT LGPIWGMISR KADPTYGISP 240
NGKFSTPWWF TSLYARITGA HNETATFNNN FANVPSSQRE TRTFSGRGQR LGTAPATLSQ 300
TSGTDSGRAS GSQLRSGPSN LNQFQGRGQR VGQTNSPSDS Q 342
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-1185--Reference proteome
KW-0346--Stress response
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007599--DER1

PROSITE
Pfam
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0030433--P:ER-associated ubiquitin-dependent protein catabolic process