| Tag |
Content |
| dbPAF ID |
dbPAF-0016731 |
| Uniprot Accession |
Q12692; H2AZ_YEAST; D6W255;
|
| Genbank Protein ID |
NP_014631.1;
|
| Genbank Nucleotide ID |
NM_001183266.1;
|
| Protein Name |
Histone H2A.Z |
| Protein Synonyms/Alias |
|
| Gene Name |
HTZ1 |
| Gene Synonyms/Alias |
H2AZ;HTA3;YOL012C;O2345; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.Functional Description
Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 19 | SGAKDSGSLRSQSSS | curated | 24961812 |
|
Sequence
(Fasta) | MSGKAHGGKG KSGAKDSGSL RSQSSSARAG LQFPVGRIKR YLKRHATGRT RVGSKAAIYL 60
TAVLEYLTAE VLELAGNAAK DLKVKRITPR HLQLAIRGDD ELDSLIRATI ASGGVLPHIN 120
KALLLKVEKK GSKK
135Fasta Sequence
>Q12692|HTZ1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSGKAHGGKGKSGAKDSGSLRSQSSSARAGLQFPVGRIKRYLKRHATGRTRVGSKAAIYLTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDDELDSLIRATIASGGVLPHINKALLLKVEKKGSKK
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0544--Nucleosome core
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR009072--Histone-fold
IPR002119--Histone_H2A
IPR007125--Histone_H2A/H2B/H3
IPR032454--Histone_H2A_C
IPR032458--Histone_H2A_CS
|
| PROSITE |
PS00046--HISTONE_H2A
|
| Pfam |
PF00125--Histone
PF16211--Histone_H2A_C
|
| Gene Ontology |
GO:0000790--C:nuclear chromatin
GO:0005719--C:nuclear euchromatin
GO:0000786--C:nucleosome
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0006338--P:chromatin remodeling
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0070481--P:nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
