dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016724
Uniprot Accession Q12527; ATG11_YEAST; D6W457;
Genbank Protein ID NP_015374.1;
Genbank Nucleotide ID NM_001184146.1;
Protein Name Autophagy-related protein 11
Protein Synonyms/Alias Cytoplasm to vacuole targeting protein 9;
Gene Name ATG11
Gene Synonyms/Alias CVT9;YPR049C;YP9499.07c;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for ATG9 anterograde transport from the mitochondria to the PAS. Recruits also the ATG19-prAPE1 complex to the PAS. Required for the Cvt vesicles completion. Plays a significant role in life span extension.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
130NSNDLTETLEYLIKNcurated24961812
370NSQEFLKSMNVMLEKPhosphoGRID 2.0;curated19823750; 19795423; 22817900
547EEDENENSIANYRQDcurated24961812
613SSNGNSISPEGSIALdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26040406; 22369663;
666HLKPFRGSATSINKKcurated25315811
808DYDDVSKSRERLQMDcurated24961812
853KSYAETNSSSMEKGEcurated25315811
935QSNILDESTQMLDAHdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812; 25315811
Sequence
(Fasta)		MADADEYSTA PTQQEITPLQ TTATIINAIS GECITTNVDF FVSLDKFKQF IARKWKIPPD 60
QLLILLPYGN KLKPSMFKEL LINRSFTLND FYVYDRRLFS LVSKPTPTNL LTSKDSNPMN 120
SPNSNDLTET LEYLIKNSHI SQYQGSDTIM IKPMPSPLED ADVDLSRLNY HSVTSLLTTN 180
LGWLSALEID VHYFKSLIPD IIAHIKRIFD GLTVCSQYLK LYCFDVESLY NSNVQFLNQL 240
VDNGMTSKWE KCFNDTLSKL TALEGDSLQK FINIESLLEN EKSVKILNHS INGKLNKIKR 300
EIDENASFRD IITVNIDRLR QMFTPNESKF ELEDQMAESF EVLVSEMRTR SRNVLDKEEE 360
EFNSQEFLKS MNVMLEKDKK ESVKTLFTIS QALYSQIGEL IDLKKSLQKH AVAILGNIAF 420
TQMEILGIKR LLLNECNKDL ELYKKYEVEF AQVEDLPLIY GLYLIEKYRR LSWFQQILSF 480
ISNFNQDLEL FKQNELRTRN KWVKNFGSIA TVFCEDLLSS SDFKRLNEYH SHTSPPNEDE 540
EDENENSIAN YRQDLVKVSQ AIDNYMTQIK ETDVSEPIID LLSKTLFETK RFHIIYSNFK 600
NNNNNSSNGN SISPEGSIAL KSDDVVKGYK TRIKKLESLL HEFQYSDIGH WPQGVLNTHL 660
KPFRGSATSI NKKKFLGASV LLEPANISEV NIDSVSQANN HQIQELESNV DDLLHQLQLL 720
KEENNRKSMQ ISEMGKKISD LEVEKTAYRE TLTNLNQELA RLTNEEQSHR TEIFTLNASF 780
KKQLNDIISQ DNEKIEKLTG DYDDVSKSRE RLQMDLDESN KKHEQEVNLL KADIERLGKQ 840
IVTSEKSYAE TNSSSMEKGE KFETIPLAED PGRENQISAY TQTLQDRIFD IISTNIFILE 900
NIGLLLTFDN NNNIQIRRVK GLKKGTAQSN ILDESTQMLD AHDNSLIKSP VFQKLKDEYE 960
LIKSVANGSE KDTQQSIFLG NITQLYDNKL YEVAVIRRFK DIETLAKKLT KENKIKRTLL 1020
ERFQREKVTL RNFQIGDLAL FLPTRENVNS VGSMSSSTSS LSSSFSSVDL STPPPLDAMS 1080
IQSSPSVIHS NVINQASISG RDKNKLMRPW AAFTAFEEST RYFLKDEKGL TKGKEWFVGR 1140
IVTLEHFVAD SPSNNPFRLP KGSVWFQVTA VVVSYQGV 1179
Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0926--Vacuole
Interpro

IPR019460--Autophagy-rel_p11
PROSITE
Pfam

PF10377--ATG11
Gene Ontology

GO:0019898--C:extrinsic component of membrane
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0005774--C:vacuolar membrane
GO:0032947--F:protein complex scaffold
GO:0032258--P:CVT pathway
GO:0000422--P:mitophagy
GO:0030242--P:pexophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0034497--P:protein localization to pre-autophagosomal structure
GO:0061709--P:reticulophagy