dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0016721
Uniprot Accession Q12522; IF6_YEAST; D6W426;
Genbank Protein ID NP_015341.1;
Genbank Nucleotide ID NM_001184113.1;
Protein Name Eukaryotic translation initiation factor 6
Protein Synonyms/Alias
Gene Name TIF6
Gene Synonyms/Alias CDC95;YPR016C;LPZ15C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
87ELQHLRNSLPDSVKIcurated25315811
91LRNSLPDSVKIQRVEcurated25315811
174VQDQEELSSLLQVPLPhosphoGRID 2.018256024
175QDQEELSSLLQVPLVPhosphoGRID 2.018256024
231LQDAQPESISGNLRDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 21177495; 21126336;
233DAQPESISGNLRDTLdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;curated18407956; 16381945; 23193290; 21081558; 19366988; 26040289;
Sequence
(Fasta)		MATRTQFENS NEIGVFSKLT NTYCLVAVGG SENFYSAFEA ELGDAIPIVH TTIAGTRIIG 60
RMTAGNRRGL LVPTQTTDQE LQHLRNSLPD SVKIQRVEER LSALGNVICC NDYVALVHPD 120
IDRETEELIS DVLGVEVFRQ TISGNILVGS YCSLSNQGGL VHPQTSVQDQ EELSSLLQVP 180
LVAGTVNRGS SVVGAGMVVN DYLAVTGLDT TAPELSVIES IFRLQDAQPE SISGNLRDTL 240
IETYS 246
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0690--Ribosome biogenesis
Interpro

IPR002769--eIF6
PROSITE
Pfam

PF01912--eIF-6
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0030687--C:preribosome, large subunit precursor
GO:0042802--F:identical protein binding
GO:0043023--F:ribosomal large subunit binding
GO:0043022--F:ribosome binding
GO:0003743--F:translation initiation factor activity
GO:1902626--P:assembly of large subunit precursor of preribosome
GO:0000466--P:maturation of 5
8S rRNA fr--m tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0042256--P:mature ribosome assembly
GO:0042273--P:ribosomal large subunit biogenesis
GO:0000054--P:ribosomal subunit export from nucleus
GO:0006364--P:rRNA processing