| Tag |
Content |
| dbPAF ID |
dbPAF-0016718 |
| Uniprot Accession |
Q12517; DCP1_YEAST; D6W1S0;
|
| Genbank Protein ID |
NP_014492.1;
|
| Genbank Nucleotide ID |
NM_001183403.1;
|
| Protein Name |
mRNA-decapping enzyme subunit 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
DCP1 |
| Gene Synonyms/Alias |
YOL149W; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. DCP1 is activated by the DEAD-box helicase DHH1 and destabilizes the eIF-4F cap-binding complex from the mRNA.Functional Description
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. DCP1 is activated by the DEAD-box helicase DHH1 and destabilizes the eIF-4F cap-binding complex from the mRNA. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MTGAATAAEN SATQLEFYRK ALNFNVIGRY DPKIKQLLFH TPHASLYKWD FKKDEWNKLE 60
YQGVLAIYLR DVSQNTNLLP VSPQEVDIFD SQNGSNNIQV NNGSDNSNRN SSGNGNSYKS 120
NDSLTYNCGK TLSGKDIYNY GLIILNRINP DNFSMGIVPN SVVNKRKVFN AEEDTLNPLE 180
CMGVEVKDEL VIIKNLKHEV YGIWIHTVSD RQNIYELIKY LLENEPKDSF A
232Fasta Sequence
>Q12517|DCP1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MTGAATAAENSATQLEFYRKALNFNVIGRYDPKIKQLLFHTPHASLYKWDFKKDEWNKLEYQGVLAIYLRDVSQNTNLLPVSPQEVDIFDSQNGSNNIQVNNGSDNSNRNSSGNGNSYKSNDSLTYNCGKTLSGKDIYNYGLIILNRINPDNFSMGIVPNSVVNKRKVFNAEEDTLNPLECMGVEVKDELVIIKNLKHEVYGIWIHTVSDRQNIYELIKYLLENEPKDSFA
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0866--Nonsense-mediated mRNA decay
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
|
| Interpro |
IPR010334--Dcp1
IPR011993--PH/PTB_dom
|
| PROSITE |
|
| Pfam |
PF06058--DCP1
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0000932--C:cytoplasmic mRNA processing body
GO:0005634--C:nucleus
GO:0008047--F:enzyme activator activity
GO:0003729--F:mRNA binding
GO:0000290--P:deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0031087--P:deadenylation-independent decapping of nuclear-transcribed mRNA
GO:0006397--P:mRNA processing
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0043085--P:positive regulation of catalytic activity
|
